Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells

Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-02, Vol.53 (10), p.1607-1610
Main Authors: Lim, Sungsu, Haque, Md Mamunul, Su, Dongdong, Kim, Dohee, Lee, Jun-Seok, Chang, Young-Tae, Kim, Yun Kyung
Format: Article
Language:English
Subjects:
Agglomeration
Aggregates
Disorders
Fluorescence
Imaging
Monitors
Neurons
Sensors
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Summary:Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc08826k