Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro‐ and Macroenvironments

Modular bioinks based on single cell microgels within distinct injectable prepolymers enable uncoupling of biomaterials' micro‐ and macroenvironments. These inks allow biofabrication of 3D constructs that recapitulate the multiscale modular design of native tissues with a single cell resolution...

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Bibliographic Details
Published in:Advanced healthcare materials 2017-02, Vol.6 (3), p.np-n/a
Main Authors: Kamperman, Tom, Henke, Sieger, van den Berg, Albert, Shin, Su Ryon, Tamayol, Ali, Khademhosseini, Ali, Karperien, Marcel, Leijten, Jeroen
Format: Article
Language:English
Subjects:
Animals
biofabrication
Biomaterials
Biomedical materials
Cattle
Chondrocytes - cytology
Chondrocytes - metabolism
Construction engineering
droplet microfluidics
Health care
Humans
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - metabolism
Microgels
Modular construction
multiscale hierarchical materials
Prepolymers
single cell encapsulation
Stem Cell Niche
Surgical implants
Tissue Engineering
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Summary:Modular bioinks based on single cell microgels within distinct injectable prepolymers enable uncoupling of biomaterials' micro‐ and macroenvironments. These inks allow biofabrication of 3D constructs that recapitulate the multiscale modular design of native tissues with a single cell resolution. This approach represents a major step forward in endowing engineered constructs with the multifunctionality that underlies the behavior of native tissues.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201600913