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Eligibility Criteria Specific to Pancreaticoduodenectomy for Octogenarians: Single-center Opinion
Pancreaticoduodenectomy (PD) treatment outcomes in elderly patients have been reported to be acceptable, but the eligibility criteria are not clear. To elucidate the importance of PD in octogenarians in particular, we set five eligibility criteria for elderly patients based on preoperative cardiac a...
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| Published in: | Anticancer research 2017-04, Vol.37 (4), p.2037-2043 |
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| container_end_page | 2043 |
| container_issue | 4 |
| container_start_page | 2037 |
| container_title | Anticancer research |
| container_volume | 37 |
| creator | Shiozawa, Shunichi Usui, Takebumi Kuhara, Kotaro Tsuchiya, Akira Miyauchi, Tatsuomi Kono, Teppei Shimojima, Yukio Asaka, Shinichi Yamaguchi, Kentaro Yokomizo, Hajime Shimakawa, Takeshi Yoshimatsu, Kazuhiko Katsube, Takao Naritaka, Yoshihiko |
| description | Pancreaticoduodenectomy (PD) treatment outcomes in elderly patients have been reported to be acceptable, but the eligibility criteria are not clear. To elucidate the importance of PD in octogenarians in particular, we set five eligibility criteria for elderly patients based on preoperative cardiac and pulmonary function, nutritional status, daily activity status, and psychological independence status for the first time and evaluated prospectively whether the validity of patient selection was adaptable.
The study population consisted of 222 patients with pancreaticobiliary cancer aged over 70 years. The patients were divided into two groups: 192 patients as septuagenarians and 30 as octogenarians. Postoperative morbidity and long-term outcome were compared between the two groups, and prognostic factors relating to survival time were identified.
Octogenarians had a significantly higher frequency of two or more comorbidities (p |
| doi_str_mv | 10.21873/anticanres.11549 |
| format | article |
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The study population consisted of 222 patients with pancreaticobiliary cancer aged over 70 years. The patients were divided into two groups: 192 patients as septuagenarians and 30 as octogenarians. Postoperative morbidity and long-term outcome were compared between the two groups, and prognostic factors relating to survival time were identified.
Octogenarians had a significantly higher frequency of two or more comorbidities (p<0.0001). The difference in the mortality rates between the two groups was not significant, being 3.3% and 4.2%, respectively. No difference between the two groups was found in overall survival rate, including deaths due to other diseases, for any type of pancreaticobiliary cancer. Independent prognostic factors relating to survival duration were intraoperative blood loss (p=0.0004) and duration of surgery (p=0.0093).
These five eligibility criteria for PD in elderly patients are also satisfactorily applicable to octogenarian patients. These criteria may be helpful when uncertainties arise regarding the selection of PD.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>DOI: 10.21873/anticanres.11549</identifier><identifier>PMID: 28373479</identifier><language>eng</language><publisher>Greece</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Comorbidity ; Female ; Follow-Up Studies ; Humans ; Length of Stay ; Male ; Neoplasm Staging ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - surgery ; Pancreaticoduodenectomy - mortality ; Postoperative Complications ; Prognosis ; Prospective Studies ; Risk Factors ; Survival Rate</subject><ispartof>Anticancer research, 2017-04, Vol.37 (4), p.2037-2043</ispartof><rights>Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-dc969ba8352f4e4a07cecac36d1f75fb2d09ef36845d98f4824f681f636bae003</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28373479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shiozawa, Shunichi</creatorcontrib><creatorcontrib>Usui, Takebumi</creatorcontrib><creatorcontrib>Kuhara, Kotaro</creatorcontrib><creatorcontrib>Tsuchiya, Akira</creatorcontrib><creatorcontrib>Miyauchi, Tatsuomi</creatorcontrib><creatorcontrib>Kono, Teppei</creatorcontrib><creatorcontrib>Shimojima, Yukio</creatorcontrib><creatorcontrib>Asaka, Shinichi</creatorcontrib><creatorcontrib>Yamaguchi, Kentaro</creatorcontrib><creatorcontrib>Yokomizo, Hajime</creatorcontrib><creatorcontrib>Shimakawa, Takeshi</creatorcontrib><creatorcontrib>Yoshimatsu, Kazuhiko</creatorcontrib><creatorcontrib>Katsube, Takao</creatorcontrib><creatorcontrib>Naritaka, Yoshihiko</creatorcontrib><title>Eligibility Criteria Specific to Pancreaticoduodenectomy for Octogenarians: Single-center Opinion</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Pancreaticoduodenectomy (PD) treatment outcomes in elderly patients have been reported to be acceptable, but the eligibility criteria are not clear. To elucidate the importance of PD in octogenarians in particular, we set five eligibility criteria for elderly patients based on preoperative cardiac and pulmonary function, nutritional status, daily activity status, and psychological independence status for the first time and evaluated prospectively whether the validity of patient selection was adaptable.
The study population consisted of 222 patients with pancreaticobiliary cancer aged over 70 years. The patients were divided into two groups: 192 patients as septuagenarians and 30 as octogenarians. Postoperative morbidity and long-term outcome were compared between the two groups, and prognostic factors relating to survival time were identified.
Octogenarians had a significantly higher frequency of two or more comorbidities (p<0.0001). The difference in the mortality rates between the two groups was not significant, being 3.3% and 4.2%, respectively. No difference between the two groups was found in overall survival rate, including deaths due to other diseases, for any type of pancreaticobiliary cancer. Independent prognostic factors relating to survival duration were intraoperative blood loss (p=0.0004) and duration of surgery (p=0.0093).
These five eligibility criteria for PD in elderly patients are also satisfactorily applicable to octogenarian patients. These criteria may be helpful when uncertainties arise regarding the selection of PD.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Neoplasm Staging</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Pancreaticoduodenectomy - mortality</subject><subject>Postoperative Complications</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Survival Rate</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpFkD1PwzAURS0EoqXwA1iQR5YUO3Zshw1V5UOqVKTCHDnOc2WU2MVOhv57orbA9O5wz33SQeiWknlOlWQP2vfOaB8hzSkteHmGplSWNJMFI-doSvKCZJKQYoKuUvoiRIhSsUs0yRWTjMtyivSydVtXu9b1e7yIrofoNN7swDjrDO4DftfeRNDjo9AMoQEPpg_dHtsQ8XqMW_B6ZHx6xBvnty1kBvw4g9c7513w1-jC6jbBzenO0Ofz8mPxmq3WL2-Lp1VmGOd91phSlLVWrMgtB66JNGC0YaKhVha2zhtSgmVC8aIpleUq51YoagUTtQZC2AzdH3d3MXwPkPqqc8lA22oPYUgVVYpTUeSEj1V6rJoYUopgq110nY77ipLqYLb6N1sdzI7M3Wl-qDto_ohflewHhkR5UA</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Shiozawa, Shunichi</creator><creator>Usui, Takebumi</creator><creator>Kuhara, Kotaro</creator><creator>Tsuchiya, Akira</creator><creator>Miyauchi, Tatsuomi</creator><creator>Kono, Teppei</creator><creator>Shimojima, Yukio</creator><creator>Asaka, Shinichi</creator><creator>Yamaguchi, Kentaro</creator><creator>Yokomizo, Hajime</creator><creator>Shimakawa, Takeshi</creator><creator>Yoshimatsu, Kazuhiko</creator><creator>Katsube, Takao</creator><creator>Naritaka, Yoshihiko</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201704</creationdate><title>Eligibility Criteria Specific to Pancreaticoduodenectomy for Octogenarians: Single-center Opinion</title><author>Shiozawa, Shunichi ; Usui, Takebumi ; Kuhara, Kotaro ; Tsuchiya, Akira ; Miyauchi, Tatsuomi ; Kono, Teppei ; Shimojima, Yukio ; Asaka, Shinichi ; Yamaguchi, Kentaro ; Yokomizo, Hajime ; Shimakawa, Takeshi ; Yoshimatsu, Kazuhiko ; Katsube, Takao ; Naritaka, Yoshihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-dc969ba8352f4e4a07cecac36d1f75fb2d09ef36845d98f4824f681f636bae003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Neoplasm Staging</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Pancreaticoduodenectomy - mortality</topic><topic>Postoperative Complications</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shiozawa, Shunichi</creatorcontrib><creatorcontrib>Usui, Takebumi</creatorcontrib><creatorcontrib>Kuhara, Kotaro</creatorcontrib><creatorcontrib>Tsuchiya, Akira</creatorcontrib><creatorcontrib>Miyauchi, Tatsuomi</creatorcontrib><creatorcontrib>Kono, Teppei</creatorcontrib><creatorcontrib>Shimojima, Yukio</creatorcontrib><creatorcontrib>Asaka, Shinichi</creatorcontrib><creatorcontrib>Yamaguchi, Kentaro</creatorcontrib><creatorcontrib>Yokomizo, Hajime</creatorcontrib><creatorcontrib>Shimakawa, Takeshi</creatorcontrib><creatorcontrib>Yoshimatsu, Kazuhiko</creatorcontrib><creatorcontrib>Katsube, Takao</creatorcontrib><creatorcontrib>Naritaka, Yoshihiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shiozawa, Shunichi</au><au>Usui, Takebumi</au><au>Kuhara, Kotaro</au><au>Tsuchiya, Akira</au><au>Miyauchi, Tatsuomi</au><au>Kono, Teppei</au><au>Shimojima, Yukio</au><au>Asaka, Shinichi</au><au>Yamaguchi, Kentaro</au><au>Yokomizo, Hajime</au><au>Shimakawa, Takeshi</au><au>Yoshimatsu, Kazuhiko</au><au>Katsube, Takao</au><au>Naritaka, Yoshihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eligibility Criteria Specific to Pancreaticoduodenectomy for Octogenarians: Single-center Opinion</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2017-04</date><risdate>2017</risdate><volume>37</volume><issue>4</issue><spage>2037</spage><epage>2043</epage><pages>2037-2043</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Pancreaticoduodenectomy (PD) treatment outcomes in elderly patients have been reported to be acceptable, but the eligibility criteria are not clear. To elucidate the importance of PD in octogenarians in particular, we set five eligibility criteria for elderly patients based on preoperative cardiac and pulmonary function, nutritional status, daily activity status, and psychological independence status for the first time and evaluated prospectively whether the validity of patient selection was adaptable.
The study population consisted of 222 patients with pancreaticobiliary cancer aged over 70 years. The patients were divided into two groups: 192 patients as septuagenarians and 30 as octogenarians. Postoperative morbidity and long-term outcome were compared between the two groups, and prognostic factors relating to survival time were identified.
Octogenarians had a significantly higher frequency of two or more comorbidities (p<0.0001). The difference in the mortality rates between the two groups was not significant, being 3.3% and 4.2%, respectively. No difference between the two groups was found in overall survival rate, including deaths due to other diseases, for any type of pancreaticobiliary cancer. Independent prognostic factors relating to survival duration were intraoperative blood loss (p=0.0004) and duration of surgery (p=0.0093).
These five eligibility criteria for PD in elderly patients are also satisfactorily applicable to octogenarian patients. These criteria may be helpful when uncertainties arise regarding the selection of PD.</abstract><cop>Greece</cop><pmid>28373479</pmid><doi>10.21873/anticanres.11549</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Aged Aged, 80 and over Comorbidity Female Follow-Up Studies Humans Length of Stay Male Neoplasm Staging Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Pancreaticoduodenectomy - mortality Postoperative Complications Prognosis Prospective Studies Risk Factors Survival Rate |
| title | Eligibility Criteria Specific to Pancreaticoduodenectomy for Octogenarians: Single-center Opinion |
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