The role of ILC2 in hookworm infection

Summary Hookworm is a major public health concern, yet still relatively little is known about the immunological responses involved in human infection. Animal studies are mainly confined to using the natural rodent helminth Nippostrongylus brasiliensis as this has been proposed as the most accurate m...

Full description

Saved in:
Bibliographic Details
Published in:Parasite immunology 2018-02, Vol.40 (2), p.n/a
Main Authors: Filbey, K., Bouchery, T., Le Gros, G.
Format: Article
Language:English
Subjects:
Ancylostomatoidea - immunology
Animals
Cytokines - immunology
Disease Models, Animal
Female
hookworm
Hookworm Infections - immunology
Hookworm Infections - parasitology
Humans
Immune response
Immunity, Innate - immunology
Immunological tolerance
Infections
innate immunity
innate lymphoid cell, cytokine
Life cycles
Lymphoid cells
Male
Mice
Necator americanus
Neglected Diseases - immunology
Neglected Diseases - parasitology
Nippostrongylus - immunology
Nippostrongylus brasiliensis
Public health
Th2 Cells - immunology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Hookworm is a major public health concern, yet still relatively little is known about the immunological responses involved in human infection. Animal studies are mainly confined to using the natural rodent helminth Nippostrongylus brasiliensis as this has been proposed as the most accurate model of hookworm infection in the mouse, with both its life cycle and the immune responses it invokes having been extremely well characterized. In this review, we examine the roles that type 2 innate lymphoid cells (ILC2s) play in immunity and host tolerance to hookworm infection, particularly N. brasiliensis. This includes their role in the initiation and regulation of immune responses, as well as in the resolution and limitation of tissue damage required after an infection with a large organism, such as a helminth.
ISSN:0141-9838
1365-3024
DOI:10.1111/pim.12429