Characteristics and Impacts of Venous Thromboembolism in Patients with Hepatocellular Carcinoma

Introduction Venous thromboembolism (VTE) is a common complication in cancer patients, and is associated with worse prognosis in such population. Hepatocellular carcinoma (HCC) poses high risk for VTE; however, data is scarce regarding the characteristics and consequences of VTE in HCC patients. Met...

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Bibliographic Details
Published in:Journal of gastrointestinal cancer 2018-09, Vol.49 (3), p.275-282
Main Authors: Wang, Yuchen, Attar, B. M., Hinami, K., Fuentes, H. E., Jaiswal, P., Zhang, H., Simons-Linares, C. S., Tafur, A. J.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cancer Research
Carcinoma, Hepatocellular - complications
Carcinoma, Hepatocellular - drug therapy
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - surgery
Chicago - epidemiology
Cohort Studies
Female
Gastroenterology
Humans
Incidence
Internal Medicine
Liver Neoplasms - complications
Liver Neoplasms - drug therapy
Liver Neoplasms - mortality
Liver Neoplasms - surgery
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Research
Prognosis
Radiotherapy
Retrospective Studies
Risk Factors
Survival Analysis
Venous Thromboembolism - diagnosis
Venous Thromboembolism - epidemiology
Venous Thromboembolism - etiology
Venous Thromboembolism - mortality
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Summary:Introduction Venous thromboembolism (VTE) is a common complication in cancer patients, and is associated with worse prognosis in such population. Hepatocellular carcinoma (HCC) poses high risk for VTE; however, data is scarce regarding the characteristics and consequences of VTE in HCC patients. Method We retrospectively reviewed the electronic medical records (EMR) of 270 patients diagnosed with HCC from 2000 to 2015 in Cook County Health and Hospitals System. We report the cumulative incidence of VTE in the present cohort, and identified through multivariate logistic regression the independent risk factors of the development of VTE. Overall prognosis of patients with and without VTE were presented and compared. Results Sixteen cases (5.93%) of VTE were documented in the present study. In multivariate analysis, obesity, Child B cirrhosis, intra-hepatic lesions more than 3, and multi-organ extrahepatic metastasis were significantly associated with VTE development ( p  
ISSN:1941-6628
1941-6636
DOI:10.1007/s12029-017-9945-6