Evaluation of splenic perfusion and spleen size using dynamic computed tomography: Usefulness in assessing degree of liver fibrosis

Aim To enhance the usefulness of splenic perfusion evaluated by means of dynamic computed tomography (CT) and spleen size in assessing the degree of liver fibrosis. Methods We retrospectively studied 133 patients who had undergone dynamic CT before hepatectomy. Fibrosis was histologically establishe...

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Bibliographic Details
Published in:Hepatology research 2018-01, Vol.48 (1), p.87-93
Main Authors: Suzuki, Takeshi, Yamada, Akira, Komatsu, Daisuke, Kurozumi, Masahiro, Fujinaga, Yasunari, Ueda, Kazuhiko, Miyagawa, Shinichi, Kadoya, Masumi
Format: Article
Language:English
Subjects:
Computed tomography
Fibrosis
Hepatectomy
Hepatitis
Hepatitis B
Hepatitis C
Liver
liver fibrosis
multidetector computed tomography
Perfusion
portal hypertension
Spleen
Viral infections
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Summary:Aim To enhance the usefulness of splenic perfusion evaluated by means of dynamic computed tomography (CT) and spleen size in assessing the degree of liver fibrosis. Methods We retrospectively studied 133 patients who had undergone dynamic CT before hepatectomy. Fibrosis was histologically established in all. First we calculated splenic perfusion parameters K1 (inflow rate constant), 1/k2 (mean transit time; MTT), and K1/k2 (distribution volume; Vd), using compartment model analysis. Then we compared the stage of fibrosis with splenic perfusion and spleen size (long axis, R), using the Kruskal–Wallis test and multiple comparisons. After that, we assessed the diagnostic accuracy of the combination of splenic perfusion, spleen size, age, gender, and the presence or absence of hepatitis B and hepatitis C viral infection in detecting liver fibrosis, using stepwise regression and receiver operating characteristic analysis. Results Significant differences (P 
ISSN:1386-6346
1872-034X
DOI:10.1111/hepr.12900