Angiogenic effects of low-intensity cathodal direct current on ischemic diabetic foot ulcers: A randomized controlled trial

Highlights • A mechanism for the therapeutic effects of electrical stimulation (ES) on wound healing is proposed. • The mechanism relies on the release of HIF-1α and VEGF in the wound area of ischemic diabetic foot ulcers following application of electrical stimulation. • ES, with parameters used in...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2017-05, Vol.127, p.147-155
Main Authors: Asadi, Mohammad Reza, Torkaman, Giti, Hedayati, Mehdi, Mohajeri-Tehrani, Mohammad Reza, Ahmadi, Mousa, Gohardani, Roghieh Fathi
Format: Article
Language:English
Subjects:
Diabetes Mellitus, Type 2 - complications
Diabetic Foot - therapy
Diabetic foot ulcers
Electric Stimulation - methods
Electrical stimulation
Endocrinology & Metabolism
Female
HIF-1α
Humans
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Male
Middle Aged
Neovascularization, Pathologic - metabolism
Nitric Oxide - metabolism
Vascular Endothelial Growth Factor A - metabolism
VEGF
VEGFR-2
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Summary:Highlights • A mechanism for the therapeutic effects of electrical stimulation (ES) on wound healing is proposed. • The mechanism relies on the release of HIF-1α and VEGF in the wound area of ischemic diabetic foot ulcers following application of electrical stimulation. • ES, with parameters used in this study, has positive effects on the release of angiogenic factors and reduction of wound surface area in ischemic diabetic foot ulcers.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2017.03.012