Lower‐limb muscle function is a determinant of exercise tolerance after lung resection surgery in patients with lung cancer

Background and objective This study aims to investigate the association between exercise tolerance, pulmonary function and lower‐limb muscle function in patients with lung cancer who underwent lung resection surgery in the previous year. Methods Sixty‐four patients (age: 67 ± 11 years, 66% males) pe...

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Bibliographic Details
Published in:Respirology (Carlton, Vic.) Vic.), 2017-08, Vol.22 (6), p.1185-1189
Main Authors: Burtin, Chris, Franssen, Frits M.E., Vanfleteren, Lowie E.G.W., Groenen, Miriam T.J., Wouters, Emiel F.M., Spruit, Martijn A.
Format: Article
Language:English
Subjects:
6‐min walking distance
Aerobic capacity
Aged
Body weight
Carbon monoxide
Correlation analysis
Cross-Sectional Studies
Exercise
Exercise Test
Exercise Tolerance - physiology
Female
Humans
Lung cancer
Lung Neoplasms - physiopathology
Lung Neoplasms - surgery
Male
Middle Aged
Muscle contraction
Muscle function
Muscle strength
Muscle Strength - physiology
Muscles
Oxygen Consumption
peak aerobic capacity
Physical training
Pneumonectomy
quadriceps endurance
Quadriceps muscle
Quadriceps Muscle - physiopathology
quadriceps strength
Respiratory diseases
Respiratory function
Respiratory Function Tests
Studies
Surgery
Walking
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Summary:Background and objective This study aims to investigate the association between exercise tolerance, pulmonary function and lower‐limb muscle function in patients with lung cancer who underwent lung resection surgery in the previous year. Methods Sixty‐four patients (age: 67 ± 11 years, 66% males) performed a symptom‐limited incremental cycle test to define peak oxygen consumption (VO2peak) and peak workload (Wpeak). The best of two 6‐min walking distance (6MWD) tests was also included. Isometric quadriceps strength and isokinetic quadriceps endurance were measured. Post‐bronchodilator spirometry, lung volumes and diffusing capacity of the lung for carbon monoxide (DLCO ) measurements were assessed. Univariate correlation analysis and multiple regression analyses were performed. Results VO2 peak, W peak and 6MWD showed moderate to strong correlations with quadriceps strength/endurance and DLCO while weak to moderate correlations were found with forced expiratory volume in 1 s (FEV1 ), functional residual capacity (FRC) and body weight. Multiple regression showed that peak isometric quadriceps strength (P 
ISSN:1323-7799
1440-1843
DOI:10.1111/resp.13041