Inheritance: Male mtDNA Just Can’t Catch a Break

Mitochondrial DNA (mtDNA) is actively eliminated from the developing sperm in Drosophila. New work shows that the mitochondrial DNA polymerase, which normally replicates mtDNA, plays a surprising role in mtDNA elimination. Mitochondrial DNA (mtDNA) is actively eliminated from the developing sperm in...

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Bibliographic Details
Published in:Current biology 2017-04, Vol.27 (7), p.R264-R266
Main Author: Patel, Maulik R.
Format: Article
Language:English
Subjects:
Animals
DNA Polymerase gamma
DNA, Mitochondrial
Genome, Mitochondrial
Male
Mitochondria - genetics
Spermatozoa
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Summary:Mitochondrial DNA (mtDNA) is actively eliminated from the developing sperm in Drosophila. New work shows that the mitochondrial DNA polymerase, which normally replicates mtDNA, plays a surprising role in mtDNA elimination. Mitochondrial DNA (mtDNA) is actively eliminated from the developing sperm in Drosophila. New work shows that the mitochondrial DNA polymerase, which normally replicates mtDNA, plays a surprising role in mtDNA elimination.
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2017.02.057