Circadian Disruption and Prostate Cancer Risk: An Updated Review of Epidemiological Evidences

Since the publication of the International Agency for Research on Cancer Monograph in 2007 classifying night shift work leading to a disruption of circadian rhythm as probably carcinogenic to humans, there is an increasingly growing interest in understanding how circadian disruption may play a role...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2017-07, Vol.26 (7), p.985-991
Main Authors: Wendeu-Foyet, Méyomo G, Menegaux, Florence
Format: Article
Language:English
Subjects:
Biological clocks
Biomarkers
Carcinogenesis - metabolism
Cell Proliferation
Chronobiology Disorders - complications
Chronobiology Disorders - metabolism
Circadian rhythm
Circadian Rhythm - physiology
Circadian Rhythm Signaling Peptides and Proteins - metabolism
Circadian rhythms
Disruption
Epidemiology
Health risk assessment
Health risks
Humans
Incidence
Male
Melatonin - metabolism
Night shifts
Nighttime
Prostate cancer
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - metabolism
Reviews
Risk Factors
Shift work
Shift Work Schedule - adverse effects
Sleep
Work Schedule Tolerance - physiology
Working conditions
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Summary:Since the publication of the International Agency for Research on Cancer Monograph in 2007 classifying night shift work leading to a disruption of circadian rhythm as probably carcinogenic to humans, there is an increasingly growing interest in understanding how circadian disruption may play a role in cancer development.This systematic review provides a comprehensive update on epidemiologic evidences on circadian disruption and prostate cancer since the last review published in 2012. We identified 12 new studies evaluating the effects of several circadian disruptors such as night shift work, sleep patterns, and circadian genes in prostate cancer risk. In contrast, no new studies have focused on exposure to light at night.Several convincing and biologically plausible hypotheses have been proposed to understand how circadian disruption may be related to cancer. However, the current difficulty of concluding on the role of circadian disruption on prostate cancer risk requires further studies including a better characterization of the different night shift systems, data on sleep patterns and chronotype, measurement of biomarkers, and investigations of polymorphisms in the genes regulating the biological clock. .
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.epi-16-1030