Building Capability for Clinical Pharmacology Research in Sub‐Saharan Africa

A strong scientific rationale exists for conducting clinical pharmacology studies in target populations because local factors such as genetics, environment, comorbidities, and diet can affect variability in drug responses. However, clinical pharmacology studies are not widely conducted in sub‐Sahara...

Full description

Saved in:
Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2017-11, Vol.102 (5), p.786-795
Main Authors: Gutierrez, MM, Pillai, G, Felix, S, Romero, F, Onyango, KO, Owusu‐Agyei, S, Asante, KP, Barnes, KI, Sinxadi, P, Allen, E, Abdulla, S, Masimirembwa, C, Munyoro, M, Yimer, G, Gebre‐Mariam, T, Spector, J, Ogutu, B
Format: Article
Language:English
Subjects:
Africa South of the Sahara - epidemiology
Biomedical Research - methods
Biomedical Research - trends
Clinical Trials as Topic - methods
Humans
International Cooperation
Pharmacogenetics - methods
Pharmacogenetics - trends
Pharmacology, Clinical - methods
Pharmacology, Clinical - trends
Public-Private Sector Partnerships - trends
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c3175-ba7285807fc5d128c0aa39f26ecb9de2d596ca0e66287142442d6d8f5634bbc13
cites cdi_FETCH-LOGICAL-c3175-ba7285807fc5d128c0aa39f26ecb9de2d596ca0e66287142442d6d8f5634bbc13
container_end_page 795
container_issue 5
container_start_page 786
container_title Clinical pharmacology and therapeutics
container_volume 102
creator Gutierrez, MM
Pillai, G
Felix, S
Romero, F
Onyango, KO
Owusu‐Agyei, S
Asante, KP
Barnes, KI
Sinxadi, P
Allen, E
Abdulla, S
Masimirembwa, C
Munyoro, M
Yimer, G
Gebre‐Mariam, T
Spector, J
Ogutu, B
description A strong scientific rationale exists for conducting clinical pharmacology studies in target populations because local factors such as genetics, environment, comorbidities, and diet can affect variability in drug responses. However, clinical pharmacology studies are not widely conducted in sub‐Saharan Africa, in part due to limitations in technical expertise and infrastructure. Since 2012, a novel public‐private partnership model involving research institutions and a pharmaceutical company has been applied to developing increased capability for clinical pharmacology research in multiple African countries.
doi_str_mv 10.1002/cpt.695
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1884477073</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1884477073</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3175-ba7285807fc5d128c0aa39f26ecb9de2d596ca0e66287142442d6d8f5634bbc13</originalsourceid><addsrcrecordid>eNp1kN1KwzAYhoMobk7xDqRnCtKZnyZND2fxD0SHm8chTdMtkrYzWZGeeQleo1dixqZnHn28fA_PwQPAKYJjBCG-Uqv1mGV0DwwRJThmlNB9MIQQZnGGCRuAI-_fwkwyzg_BAHOS8gySIXi67owtTbOIcrmShbFm3UdV66LcmsYoaaPpUrpaqta2iz560V5Lp5aRaaJZV3x_fs1k-MsmmlQu4MfgoJLW65PdHYHX25t5fh8_Pt895JPHWBGU0riQKeaUw7RStESYKyglySrMtCqyUuOSZkxJqBnDPEUJThJcspJXlJGkKBQiI3Cx9a5c-95pvxa18UpbKxvddl4gzpMkTWFKAnq-RZVrvXe6Eitnaul6gaDYxBMhngjxAnm2k3ZFrcs_7rdWAC63wIexuv_PI_LpfKP7AW6xeDY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1884477073</pqid></control><display><type>article</type><title>Building Capability for Clinical Pharmacology Research in Sub‐Saharan Africa</title><source>Wiley</source><creator>Gutierrez, MM ; Pillai, G ; Felix, S ; Romero, F ; Onyango, KO ; Owusu‐Agyei, S ; Asante, KP ; Barnes, KI ; Sinxadi, P ; Allen, E ; Abdulla, S ; Masimirembwa, C ; Munyoro, M ; Yimer, G ; Gebre‐Mariam, T ; Spector, J ; Ogutu, B</creator><creatorcontrib>Gutierrez, MM ; Pillai, G ; Felix, S ; Romero, F ; Onyango, KO ; Owusu‐Agyei, S ; Asante, KP ; Barnes, KI ; Sinxadi, P ; Allen, E ; Abdulla, S ; Masimirembwa, C ; Munyoro, M ; Yimer, G ; Gebre‐Mariam, T ; Spector, J ; Ogutu, B</creatorcontrib><description>A strong scientific rationale exists for conducting clinical pharmacology studies in target populations because local factors such as genetics, environment, comorbidities, and diet can affect variability in drug responses. However, clinical pharmacology studies are not widely conducted in sub‐Saharan Africa, in part due to limitations in technical expertise and infrastructure. Since 2012, a novel public‐private partnership model involving research institutions and a pharmaceutical company has been applied to developing increased capability for clinical pharmacology research in multiple African countries.</description><identifier>ISSN: 0009-9236</identifier><identifier>EISSN: 1532-6535</identifier><identifier>DOI: 10.1002/cpt.695</identifier><identifier>PMID: 28378903</identifier><language>eng</language><publisher>United States</publisher><subject>Africa South of the Sahara - epidemiology ; Biomedical Research - methods ; Biomedical Research - trends ; Clinical Trials as Topic - methods ; Humans ; International Cooperation ; Pharmacogenetics - methods ; Pharmacogenetics - trends ; Pharmacology, Clinical - methods ; Pharmacology, Clinical - trends ; Public-Private Sector Partnerships - trends</subject><ispartof>Clinical pharmacology and therapeutics, 2017-11, Vol.102 (5), p.786-795</ispartof><rights>2017 American Society for Clinical Pharmacology and Therapeutics</rights><rights>2017 The Authors Clinical Pharmacology &amp; Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3175-ba7285807fc5d128c0aa39f26ecb9de2d596ca0e66287142442d6d8f5634bbc13</citedby><cites>FETCH-LOGICAL-c3175-ba7285807fc5d128c0aa39f26ecb9de2d596ca0e66287142442d6d8f5634bbc13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28378903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gutierrez, MM</creatorcontrib><creatorcontrib>Pillai, G</creatorcontrib><creatorcontrib>Felix, S</creatorcontrib><creatorcontrib>Romero, F</creatorcontrib><creatorcontrib>Onyango, KO</creatorcontrib><creatorcontrib>Owusu‐Agyei, S</creatorcontrib><creatorcontrib>Asante, KP</creatorcontrib><creatorcontrib>Barnes, KI</creatorcontrib><creatorcontrib>Sinxadi, P</creatorcontrib><creatorcontrib>Allen, E</creatorcontrib><creatorcontrib>Abdulla, S</creatorcontrib><creatorcontrib>Masimirembwa, C</creatorcontrib><creatorcontrib>Munyoro, M</creatorcontrib><creatorcontrib>Yimer, G</creatorcontrib><creatorcontrib>Gebre‐Mariam, T</creatorcontrib><creatorcontrib>Spector, J</creatorcontrib><creatorcontrib>Ogutu, B</creatorcontrib><title>Building Capability for Clinical Pharmacology Research in Sub‐Saharan Africa</title><title>Clinical pharmacology and therapeutics</title><addtitle>Clin Pharmacol Ther</addtitle><description>A strong scientific rationale exists for conducting clinical pharmacology studies in target populations because local factors such as genetics, environment, comorbidities, and diet can affect variability in drug responses. However, clinical pharmacology studies are not widely conducted in sub‐Saharan Africa, in part due to limitations in technical expertise and infrastructure. Since 2012, a novel public‐private partnership model involving research institutions and a pharmaceutical company has been applied to developing increased capability for clinical pharmacology research in multiple African countries.</description><subject>Africa South of the Sahara - epidemiology</subject><subject>Biomedical Research - methods</subject><subject>Biomedical Research - trends</subject><subject>Clinical Trials as Topic - methods</subject><subject>Humans</subject><subject>International Cooperation</subject><subject>Pharmacogenetics - methods</subject><subject>Pharmacogenetics - trends</subject><subject>Pharmacology, Clinical - methods</subject><subject>Pharmacology, Clinical - trends</subject><subject>Public-Private Sector Partnerships - trends</subject><issn>0009-9236</issn><issn>1532-6535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kN1KwzAYhoMobk7xDqRnCtKZnyZND2fxD0SHm8chTdMtkrYzWZGeeQleo1dixqZnHn28fA_PwQPAKYJjBCG-Uqv1mGV0DwwRJThmlNB9MIQQZnGGCRuAI-_fwkwyzg_BAHOS8gySIXi67owtTbOIcrmShbFm3UdV66LcmsYoaaPpUrpaqta2iz560V5Lp5aRaaJZV3x_fs1k-MsmmlQu4MfgoJLW65PdHYHX25t5fh8_Pt895JPHWBGU0riQKeaUw7RStESYKyglySrMtCqyUuOSZkxJqBnDPEUJThJcspJXlJGkKBQiI3Cx9a5c-95pvxa18UpbKxvddl4gzpMkTWFKAnq-RZVrvXe6Eitnaul6gaDYxBMhngjxAnm2k3ZFrcs_7rdWAC63wIexuv_PI_LpfKP7AW6xeDY</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Gutierrez, MM</creator><creator>Pillai, G</creator><creator>Felix, S</creator><creator>Romero, F</creator><creator>Onyango, KO</creator><creator>Owusu‐Agyei, S</creator><creator>Asante, KP</creator><creator>Barnes, KI</creator><creator>Sinxadi, P</creator><creator>Allen, E</creator><creator>Abdulla, S</creator><creator>Masimirembwa, C</creator><creator>Munyoro, M</creator><creator>Yimer, G</creator><creator>Gebre‐Mariam, T</creator><creator>Spector, J</creator><creator>Ogutu, B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201711</creationdate><title>Building Capability for Clinical Pharmacology Research in Sub‐Saharan Africa</title><author>Gutierrez, MM ; Pillai, G ; Felix, S ; Romero, F ; Onyango, KO ; Owusu‐Agyei, S ; Asante, KP ; Barnes, KI ; Sinxadi, P ; Allen, E ; Abdulla, S ; Masimirembwa, C ; Munyoro, M ; Yimer, G ; Gebre‐Mariam, T ; Spector, J ; Ogutu, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3175-ba7285807fc5d128c0aa39f26ecb9de2d596ca0e66287142442d6d8f5634bbc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Africa South of the Sahara - epidemiology</topic><topic>Biomedical Research - methods</topic><topic>Biomedical Research - trends</topic><topic>Clinical Trials as Topic - methods</topic><topic>Humans</topic><topic>International Cooperation</topic><topic>Pharmacogenetics - methods</topic><topic>Pharmacogenetics - trends</topic><topic>Pharmacology, Clinical - methods</topic><topic>Pharmacology, Clinical - trends</topic><topic>Public-Private Sector Partnerships - trends</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gutierrez, MM</creatorcontrib><creatorcontrib>Pillai, G</creatorcontrib><creatorcontrib>Felix, S</creatorcontrib><creatorcontrib>Romero, F</creatorcontrib><creatorcontrib>Onyango, KO</creatorcontrib><creatorcontrib>Owusu‐Agyei, S</creatorcontrib><creatorcontrib>Asante, KP</creatorcontrib><creatorcontrib>Barnes, KI</creatorcontrib><creatorcontrib>Sinxadi, P</creatorcontrib><creatorcontrib>Allen, E</creatorcontrib><creatorcontrib>Abdulla, S</creatorcontrib><creatorcontrib>Masimirembwa, C</creatorcontrib><creatorcontrib>Munyoro, M</creatorcontrib><creatorcontrib>Yimer, G</creatorcontrib><creatorcontrib>Gebre‐Mariam, T</creatorcontrib><creatorcontrib>Spector, J</creatorcontrib><creatorcontrib>Ogutu, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gutierrez, MM</au><au>Pillai, G</au><au>Felix, S</au><au>Romero, F</au><au>Onyango, KO</au><au>Owusu‐Agyei, S</au><au>Asante, KP</au><au>Barnes, KI</au><au>Sinxadi, P</au><au>Allen, E</au><au>Abdulla, S</au><au>Masimirembwa, C</au><au>Munyoro, M</au><au>Yimer, G</au><au>Gebre‐Mariam, T</au><au>Spector, J</au><au>Ogutu, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Building Capability for Clinical Pharmacology Research in Sub‐Saharan Africa</atitle><jtitle>Clinical pharmacology and therapeutics</jtitle><addtitle>Clin Pharmacol Ther</addtitle><date>2017-11</date><risdate>2017</risdate><volume>102</volume><issue>5</issue><spage>786</spage><epage>795</epage><pages>786-795</pages><issn>0009-9236</issn><eissn>1532-6535</eissn><abstract>A strong scientific rationale exists for conducting clinical pharmacology studies in target populations because local factors such as genetics, environment, comorbidities, and diet can affect variability in drug responses. However, clinical pharmacology studies are not widely conducted in sub‐Saharan Africa, in part due to limitations in technical expertise and infrastructure. Since 2012, a novel public‐private partnership model involving research institutions and a pharmaceutical company has been applied to developing increased capability for clinical pharmacology research in multiple African countries.</abstract><cop>United States</cop><pmid>28378903</pmid><doi>10.1002/cpt.695</doi><tpages>10</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0009-9236
ispartof Clinical pharmacology and therapeutics, 2017-11, Vol.102 (5), p.786-795
issn 0009-9236
1532-6535
language eng
recordid cdi_proquest_miscellaneous_1884477073
source Wiley
subjects Africa South of the Sahara - epidemiology
Biomedical Research - methods
Biomedical Research - trends
Clinical Trials as Topic - methods
Humans
International Cooperation
Pharmacogenetics - methods
Pharmacogenetics - trends
Pharmacology, Clinical - methods
Pharmacology, Clinical - trends
Public-Private Sector Partnerships - trends
title Building Capability for Clinical Pharmacology Research in Sub‐Saharan Africa
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T14%3A14%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Building%20Capability%20for%20Clinical%20Pharmacology%20Research%20in%20Sub%E2%80%90Saharan%20Africa&rft.jtitle=Clinical%20pharmacology%20and%20therapeutics&rft.au=Gutierrez,%20MM&rft.date=2017-11&rft.volume=102&rft.issue=5&rft.spage=786&rft.epage=795&rft.pages=786-795&rft.issn=0009-9236&rft.eissn=1532-6535&rft_id=info:doi/10.1002/cpt.695&rft_dat=%3Cproquest_cross%3E1884477073%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3175-ba7285807fc5d128c0aa39f26ecb9de2d596ca0e66287142442d6d8f5634bbc13%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1884477073&rft_id=info:pmid/28378903&rfr_iscdi=true