Comparison of preterm and term equivalent age MRI for the evaluation of preterm brain injury

Objective: To compare information obtained from preterm magnetic resonance imaging (MRI; 31–34 weeks) brain scan to that done at term equivalent age. Study design: Prospective observational study of premature infants with evidence or suspicion of parenchymal brain injury on cranial ultrasound. Brain...

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Bibliographic Details
Published in:Journal of perinatology 2017-07, Vol.37 (7), p.864-868
Main Authors: Malhotra, A, Fahey, M C, Davies-Tuck, M, Wong, F, Carse, E, Whiteley, G, Ditchfield, M
Format: Article
Language:English
Subjects:
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Age
Birth Weight
Brain
Brain - diagnostic imaging
Brain - pathology
Brain injuries
Brain Injuries - diagnostic imaging
Brain injury
Comparative analysis
Correlation analysis
Correlation coefficient
Correlation coefficients
Data processing
Diagnosis
Echoencephalography
Equivalence
Feasibility studies
Female
Gestation
Head injuries
Health aspects
Humans
Infant
Infant, Newborn
Infant, Premature
Infants
Injuries
Injury analysis
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Neuroimaging
NMR
Nuclear magnetic resonance
original-article
Patient outcomes
Pediatric Surgery
Pediatrics
Premature infants
Prospective Studies
Severity of Illness Index
Skull
Term Birth
Traumatic brain injury
Ultrasound
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Summary:Objective: To compare information obtained from preterm magnetic resonance imaging (MRI; 31–34 weeks) brain scan to that done at term equivalent age. Study design: Prospective observational study of premature infants with evidence or suspicion of parenchymal brain injury on cranial ultrasound. Brain injury on two scans scored using a scoring system and analyzed. Results: Fourteen infants with a median (range) gestation at birth of 28 (25–29) weeks and birth weight of 1254 (680–1557) grams were studied. There was a strong correlation between the brain injury scores for the two scans (Spearman ρ =0.87, P =0.001) with excellent agreement between two radiologists (interclass correlation coefficient 0.9–0.94). There was also a high level of agreement between the preterm and term MRI two scores (Intraclass correlation coefficient, 0.79 (0.53–0.94)). Conclusions: Preterm MRI is a feasible option for the assessment of preterm brain injury and analysis of data obtained from scan at preterm age is comparable to that obtained at term equivalent age.
ISSN:0743-8346
1476-5543
DOI:10.1038/jp.2017.39