Role of adenosine signaling in the pathogenesis of breast cancer

• Published in: Journal of cellular physiology 2018-03, Vol.233 (3), p.1836-1843
• Main Authors: Bahreyni, Amirhossein, Samani, Seyed Sattar, Rahmani, Farzad, Behnam‐Rassouli, Reihane, Khazaei, Majid, Ryzhikov, Mikhail, Parizadeh, Mohammad Reza, Avan, Amir, Hassanian, Seyed Mahdi
• Format: Article
• Language: English
• Subjects: 5'-Nucleotidase - metabolism; Adenosine; Adenosine - blood; Adenosine - metabolism; Adenosine receptors; Adenosine Triphosphate - metabolism; Apoptosis; Apoptosis - physiology; ATP; Breast cancer; Breast Neoplasms - pathology; Cancer; Cell Line, Tumor; Cell proliferation; Cell Proliferation - physiology; Disease control; Female; Humans; Inflammation; Inflammation - pathology; Ischemia; MCF-7 Cells; Metabolism; Metabolites; Metastases; Neoplasm Metastasis - pathology; Pathogenesis; Receptors; Receptors, Adenosine A2 - metabolism; Signal Transduction - physiology; Signaling; Tumor Microenvironment - physiology; Tumors
• ISSN: 0021-9541; 1097-4652
• DOI: 10.1002/jcp.25944

The plasma level of adenosine increases under ischemic and inflamed conditions in tumor microenvironment. Adenosine elicits a range of signaling pathways in tumors, resulting in either inhibition or enhancement of tumor growth depending upon different subtypes of adenosine receptors activation and type of cancer. Metabolism of adenosine‐5′‐triphosphate (ATP) and its derivatives including adenosine is dysregulated in the breast tumor microenvironment, supporting the role of this metabolite in the pathogenesis of breast cancer. Adenosine regulates inflammation, apoptosis, cell proliferation, and metastasis in breast cancer cells. This review summarizes the role of adenosine in the pathogenesis of breast cancer for a better understanding and hence a better management of this disease. Metabolism of adenosine‐5′‐triphosphate (ATP) and its derivatives including adenosine is dysregulated in the breast tumor microenvironment, supporting the role of this metabolite in the pathogenesis of breast cancer. Adenosine regulates inflammation, apoptosis, cell proliferation, and metastasis in breast cancer cells. This review summarizes the role of adenosine in the pathogenesis of breast cancer for a better understanding and hence a better management of this disease.