Podoplanin expression in peritumoral keratinocytes predicts aggressive behavior in extramammary Paget's disease

Highlights • Podoplanin is upregulated in peritumoral keratinocytes in invasive EMPD. • Podoplanin expression in peritumoral keratinocytes correlates with aggressive behavior in EMPD. • Podoplanin expression in peritumoral keratinocytes serve as a useful prognostic marker for patients with EMPD....

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Bibliographic Details
Published in:Journal of dermatological science 2017-07, Vol.87 (1), p.29-35
Main Authors: Cho, Zaigen, Konishi, Eiichi, Kanemaru, Mai, Isohisa, Taro, Arita, Takahiro, Kawai, Minako, Tsutsumi, Miho, Mizutani, Hiromi, Takenaka, Hideya, Ozawa, Toshiyuki, Tsuruta, Daisuke, Katoh, Norito, Asai, Jun
Format: Article
Language:English
Subjects:
Aged
Cadherins - analysis
Cell Movement
Cells, Cultured
Dermatology
Extramammary Paget's disease
Female
Genital Neoplasms, Female - pathology
Genital Neoplasms, Male - pathology
Humans
Invasion
Keratinocyte
Keratinocytes - physiology
Male
Membrane Glycoproteins - analysis
Membrane Glycoproteins - physiology
Metastasis
Neoplasm Invasiveness
Paget Disease, Extramammary - pathology
Podoplanin
Transforming Growth Factor beta - pharmacology
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Summary:Highlights • Podoplanin is upregulated in peritumoral keratinocytes in invasive EMPD. • Podoplanin expression in peritumoral keratinocytes correlates with aggressive behavior in EMPD. • Podoplanin expression in peritumoral keratinocytes serve as a useful prognostic marker for patients with EMPD.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2017.03.012