Atypical cytologic presentation of a histiocytic sarcoma in a Cavalier King Charles Spaniel dog

A Cavalier King Charles Spaniel dog was presented because of a 10-d history of progressive vomiting, inappetence, and lethargy, with mild neurologic signs. Fine-needle aspirates of splenic nodules seen on ultrasound were suggestive of a carcinoma. On autopsy, a disseminated neoplasm was present in t...

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Bibliographic Details
Published in:Journal of veterinary diagnostic investigation 2017-07, Vol.29 (4), p.541-543
Main Authors: Clarke, Lorelei L., Kelly, Lisa S., Garner, Bridget, Brown, Cathy A.
Format: Article
Language:English
Subjects:
Animals
Diagnosis, Differential
Dog Diseases - diagnosis
Dog Diseases - pathology
Dogs
Histiocytic Sarcoma - diagnosis
Histiocytic Sarcoma - pathology
Histiocytic Sarcoma - veterinary
Male
Ultrasonography
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Summary:A Cavalier King Charles Spaniel dog was presented because of a 10-d history of progressive vomiting, inappetence, and lethargy, with mild neurologic signs. Fine-needle aspirates of splenic nodules seen on ultrasound were suggestive of a carcinoma. On autopsy, a disseminated neoplasm was present in the lung, spleen, and adrenal glands. Additionally, there was a Chiari-like malformation of the skull with corresponding syringomyelia of the cranial spinal cord. Histologically, the neoplasm was comprised of a pleomorphic population of round cells with a high mitotic rate. Cells stained positive for vimentin and CD18 and negative for cytokeratin, chromogranin A, CD3, CD20, MHC II, and CD11d, and hence the tumor was diagnosed as a histiocytic sarcoma. The cytologic presentation in this case is uncommon for this type of tumor, as was the clinical presentation.
ISSN:1040-6387
1943-4936
DOI:10.1177/1040638717701521