Causes and consequences of higher Leishmania infantum burden in patients with kala‐azar: a study of 625 patients

Background An infected host's Leishmania infantum load in blood is considered to be an estimate of his or her total parasite burden. Therefore, the measurement of blood parasite burden is important in the identification of factors involved in parasite control. Methods Quantitative polymerase ch...

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Bibliographic Details
Published in:Tropical medicine & international health 2017-06, Vol.22 (6), p.679-687
Main Authors: Zacarias, Danielle A., Rolão, Nuno, Pinho, Flaviane A., Sene, Ingridi, Silva, Jailthon C., Pereira, Teresinha C., Costa, Dorcas L., Costa, Carlos H. N.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Brazil - epidemiology
carga parasitaria
charge parasitaire
Child
Child, Preschool
DNA, Kinetoplast
Female
HIV
HIV Infections - complications
Humans
Infant
kala‐azar
Leishmania donovani
Leishmania infantum
Leishmania infantum - genetics
Leishmaniasis, Visceral - epidemiology
Leishmaniasis, Visceral - parasitology
leishmaniose viscérale
leishmaniosis visceral
Male
Malnutrition - complications
Middle Aged
Nutritional Status
parasite burden
Parasitemia - parasitology
qPCR
Severity of Illness Index
Sex Factors
VIH
visceral leishmaniasis
Young Adult
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Summary:Background An infected host's Leishmania infantum load in blood is considered to be an estimate of his or her total parasite burden. Therefore, the measurement of blood parasite burden is important in the identification of factors involved in parasite control. Methods Quantitative polymerase chain reaction was performed on blood samples from 625 patients with kala‐azar consecutively admitted to a reference hospital in Teresina, Brazil. Primers were used to amplify a segment of kDNA using the TaqMan system. Non‐parametric statistical tests were applied. Results The median blood parasite burden was 499.2 amastigote equivalents (AE)/ml. Children
ISSN:1360-2276
1365-3156
DOI:10.1111/tmi.12877