Newborn dopaminergic neurons are associated with the migration and differentiation of SVZ-derived neural progenitors in a 6-hydroxydopamin-injected mouse model

• Published in: Neuroscience 2017-06, Vol.352, p.64-78
• Main Authors: Xie, M.Q, Chen, Z.C, Zhang, P, Huang, H.J, Wang, T.T, Ding, Y-Q, Qi, S.S, Zhang, C, CHEN, S.X, Zhou, P, Shao, C.C, Liao, M, Sun, C.Y
• Format: Article
• Language: English
• Subjects: 6-hydroxydopamine; AC133 Antigen - genetics; AC133 Antigen - metabolism; Adrenergic Agents - toxicity; Animals; Cell Differentiation - drug effects; Corpus Striatum - drug effects; Corpus Striatum - pathology; Disease Models, Animal; dopaminergic neuron; Dopaminergic Neurons - drug effects; Estrogen Antagonists - pharmacology; Lateral Ventricles - drug effects; Lateral Ventricles - pathology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nestin - genetics; Nestin - metabolism; neural progenitor cell; neurogenesis; Neurogenesis - drug effects; Neurology; Oxidopamine - toxicity; Parkinson Disease - etiology; Parkinson Disease - pathology; Parkinson’s disease; RNA, Untranslated - genetics; RNA, Untranslated - metabolism; substantia nigra; Substantia Nigra - drug effects; Substantia Nigra - metabolism; Tamoxifen - pharmacology
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2017.03.045

Highlights • Assess the regenerative capacity of NPCs following 6-hydroxydopamine injection. • Investigate the proliferation and differentiation of LV-, 3V-, or Aq-SVZ- and midbrain-derived NPCs. • Trace the origin of SN newborn dopaminergic neurons. • 6-hydroxydopamine injection induced an incomplete recovery in the nigrostriatal system. • SN newborn dopaminergic neurons might derive from 3V- and Aq-SVZ NPCs.