Prediction of male fertility using capacitation‐associated proteins in spermatozoa

Infertility and subfertility account for huge economic losses in the animal industry; indeed, 50% of animal breeding failure is associated with male infertility. Approximately 70% of cattle and 90% of pig livestock are currently produced by artificial insemination. Therefore, breeding‐male selection...

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Bibliographic Details
Published in:Molecular reproduction and development 2017-09, Vol.84 (9), p.749-759
Main Authors: Rahman, Md Saidur, Kwon, Woo‐Sung, Pang, Myung‐Geol
Format: Article
Language:English
Subjects:
Animal breeding
Animal husbandry
Animals
Artificial insemination
biomarkers
Breeding
Capacitation
capacitation‐associated proteins
Cattle
Clinical trials
Domestic animals
Fertility
Fertility - physiology
Fertilization
Infertility
Livestock
Male
male fertility
Males
Proteins
Proteomics
Reproductive failure
Semen
Sperm
Sperm Capacitation - physiology
spermatozoa
Spermatozoa - cytology
Spermatozoa - metabolism
Swine
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Summary:Infertility and subfertility account for huge economic losses in the animal industry; indeed, 50% of animal breeding failure is associated with male infertility. Approximately 70% of cattle and 90% of pig livestock are currently produced by artificial insemination. Therefore, breeding‐male selection is extremely important for the genetic benefits of progeny. Although conventional semen analysis provides an initial measure of male fertility, its clinical value is questionable. Proteomics approaches recently identified candidate protein markers in spermatozoa for evaluating male fertility. Fertility‐related proteins in capacitated boar spermatozoa were shown to predict boar fertility more precisely then those detected in ejaculated spermatozoa, which motivated the development of more accurate and sensitive tools for the assessment of male fertility in relation to sperm function and fertilization. Although protein markers in spermatozoa are capable of discriminating fertile and infertile males, clinical trials are required to validate their predictive utility. This review outlines recent findings regarding the capacitation‐related proteome of spermatozoa, and discusses how these proteins may be utilized to better understand the fertility of domestic animals.
ISSN:1040-452X
1098-2795
DOI:10.1002/mrd.22810