Genetic polymorphisms of NFκB1-94ins/delATTG and NFκBIA-881A/G genes in Egyptian patients with colorectal cancer

To assess the association of genetic polymorphisms of NFκB1 and NFκBIA genes with the susceptibility to colorectal cancer (CRC). Subjects included 100 Egyptian patients with CRC (60 males and 40 females) in addition to 85 healthy controls (47 males and 38 females) from the same locality. For all par...

Full description

Saved in:
Bibliographic Details
Published in:Familial cancer 2017-10, Vol.16 (4), p.517-524
Main Authors: Youssef, Mohamed Ragab, Attia, Zeinab Ibraheim, El-Baz, Rizk Ahmed, Roshdy, Sameh, Settin, Ahmad
Format: Article
Language:English
Subjects:
Alleles
Biomedical and Life Sciences
Biomedicine
Cancer Research
Colorectal cancer
Colorectal carcinoma
Epidemiology
Gene frequency
Human Genetics
NF-κB protein
Original Article
Polymerase chain reaction
Polymorphism
Restriction fragment length polymorphism
Smoking
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To assess the association of genetic polymorphisms of NFκB1 and NFκBIA genes with the susceptibility to colorectal cancer (CRC). Subjects included 100 Egyptian patients with CRC (60 males and 40 females) in addition to 85 healthy controls (47 males and 38 females) from the same locality. For all participants, genetic polymorphisms of NFκB1-94ins/delATTG (rs28362491) and NFκBIA-881A/G (rs3138053) were detected by using restriction fragment length polymorphism polymerase chain reaction (RFLP–PCR). CRC patients showed a significantly higher frequency of the NFκB1-94ins/ins genotype than controls (30 vs. 4.7%) that was significant in the recessive (OR 17.69, 95% CI   5.41–57.82, p  
ISSN:1389-9600
1573-7292
DOI:10.1007/s10689-017-9992-y