Itraconazole cis -diastereoisomers activate aryl hydrocarbon receptor AhR and pregnane X receptor PXR and induce CYP1A1 in human cell lines and human hepatocytes

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2017-05, Vol.383, p.40-49
Main Authors: Stepankova, Martina, Pastorkova, Barbora, Bachleda, Petr, Dvorak, Zdenek
Format: Article
Language:English
Subjects:
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Antifungal drug
Cell Line
Cell Line, Tumor
Cell Survival - drug effects
Cytochrome P-450 CYP3A Inhibitors - chemistry
Cytochrome P-450 CYP3A Inhibitors - pharmacology
Cytochrome P-450 Enzyme System - genetics
Cytochrome P-450 Enzyme System - metabolism
Cytochrome P450
Diastereoisomers
Emergency
Female
Gene induction
Hepatocytes - drug effects
Hepatocytes - metabolism
Human hepatocytes
Humans
Itraconazole - chemistry
Itraconazole - pharmacology
Middle Aged
Receptors, Aryl Hydrocarbon - metabolism
Receptors, Steroid - metabolism
RNA, Messenger - metabolism
Stereoisomerism
Xenoreceptors
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Description
Summary:Graphical abstract
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2017.04.002