Micro-Flow Imaging as a quantitative tool to assess size and agglomeration of PLGA microparticles

[Display omitted] The purpose of this study was to explore the potential of flow imaging microscopy to measure particle size and agglomeration of poly(lactic-co-glycolic acid) (PLGA) microparticles. The particle size distribution of pharmaceutical PLGA microparticle products is routinely determined...

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Bibliographic Details
Published in:European journal of pharmaceutics and biopharmaceutics 2017-08, Vol.117, p.91-104
Main Authors: van Beers, Miranda M.C., Slooten, Cees, Meulenaar, Jelte, Sediq, Ahmad S., Verrijk, Ruud, Jiskoot, Wim
Format: Article
Language:English
Subjects:
Agglomeration
Flow imaging microscopy
Image Processing, Computer-Assisted - methods
Lactic Acid - analysis
Lactic Acid - chemistry
Microspheres
Octreotide acetate
Particle Size
PLGA microparticles
Polyglycolic Acid - analysis
Polyglycolic Acid - chemistry
Risperidone
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Summary:[Display omitted] The purpose of this study was to explore the potential of flow imaging microscopy to measure particle size and agglomeration of poly(lactic-co-glycolic acid) (PLGA) microparticles. The particle size distribution of pharmaceutical PLGA microparticle products is routinely determined with laser diffraction. In our study, we performed a unique side-by-side comparison between MFI 5100 (flow imaging microscopy) and Mastersizer 2000 (laser diffraction) for the particle size analysis of two commercial PLGA microparticle products, i.e., Risperdal Consta and Sandostatin LAR. Both techniques gave similar results regarding the number and volume percentage of the main particle population (28–220μm for Risperdal Consta; 16–124μm for Sandostatin LAR). MFI additionally detected a ‘fines’ population (
ISSN:0939-6411
1873-3441
DOI:10.1016/j.ejpb.2017.04.002