What is the clinical significance of esophagogastric junction outflow obstruction? evaluation of 60 patients at a tertiary referral center

• Published in: Neurogastroenterology and motility 2017-06, Vol.29 (6), p.n/a
• Main Authors: Okeke, F. C., Raja, S., Lynch, K. L., Dhalla, S., Nandwani, M., Stein, E. M., Chander Roland, B., Khashab, M. A., Saxena, P., Kumbhari, V., Ahuja, N. K., Clarke, J. O.
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Barium; Botulinum toxin; Candidiasis; Clinical significance; Compression; Demography; Dysphagia; Endoscopy; Esophageal Diseases - complications; Esophageal Diseases - diagnosis; Esophageal Diseases - therapy; Esophagitis; Esophagogastric Junction - physiopathology; esophagogastric outflow obstruction (EGJOO); Esophagus; Female; Fluoroscopy; Hernia; Hernias; high‐resolution esophageal pressure topography (HREPT); Humans; Male; Middle Aged; Peristalsis; Tertiary Care Centers; Treatment Outcome; Ultrasound
• ISSN: 1350-1925; 1365-2982
• DOI: 10.1111/nmo.13061

Background Esophagogastric junction (EGJ) outflow obstruction (EGJOO) is characterized by impaired EGJ relaxation with intact or weak peristalsis. Our aims were to evaluate: (i) prevalence, (ii) yield of fluoroscopy, endoscopy, and endoscopic ultrasound (EUS), (iii) outcomes, and (iv) whether this data differed based on quantitative EGJ relaxation. Methods Studies that met criteria for EGJOO were identified. Demographics, encounters, endoscopy, radiology, treatment decisions, and outcomes were extracted. Key Results Sixty studies were identified. Dysphagia was the most common symptom. Forty patients underwent barium esophagram (BE): normal (11), hiatal hernia (20), spasm/dysmotility (17), EGJ narrowing (10), compression (2), Schatzki's ring (5), malrotation (1), gastric volvulus (1), mass (1). Esophagogastroduodenoscopy (EGD) was performed in 41 patients: normal (19), hiatal hernia (13), Schatzki's ring (6), esophagitis (3), esophageal candidiasis (3), mass (1). EUS was performed in 20 patients and was frequently normal. Twenty‐two patients underwent intervention. While transient improvement was noted in the majority, persistent improvement was seen in only one of nine patients (dilatation), four of six patients (botulinum toxin), and three patients who underwent per‐oral endoscopic myotomy. No patients treated with medical therapy alone had improvement in dysphagia. There was no difference in symptoms or outcomes based on quantitative EGJ relaxation. Conclusions & Inferences The manometric criterion EGJOO defines a heterogeneous clinical group. While BE, EGD, and EUS all provide complementary information, a significant percentage of these studies will be normal. For patients with dysphagia, outcome may depend on EGJ disruption. There were no differences in symptoms our outcomes based on quantitative EGJ relaxation.