Persistent intestinal bleeding due to severe CMV-related thrombocytopenia in a preterm newborn

The optimal threshold for neonatal platelet transfusions in sick newborns is still uncertain. We report a congenital cytomegalovirus (CMV) infection in a premature neonate with severe thrombocytopenia who subsequently presented with necrotizing enterocolitis and intestinal bleeding. The baby recover...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2018-05, Vol.31 (9), p.1246-1249
Main Authors: Berardi, Alberto, Spaggiari, Eugenio, Cattelani, Chiara, Roversi, Maria Federica, Pecorari, Monica, Lazzarotto, Tiziana, Ferrari, Fabrizio
Format: Article
Language:English
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Summary:The optimal threshold for neonatal platelet transfusions in sick newborns is still uncertain. We report a congenital cytomegalovirus (CMV) infection in a premature neonate with severe thrombocytopenia who subsequently presented with necrotizing enterocolitis and intestinal bleeding. The baby recovered after platelet transfusions were discontinued and the therapy was switched from intravenous ganciclovir to oral valganciclovir. We discuss both measures, speculating on the key role of platelet transfusions.
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2017.1312331