A Population-Based Analysis of Survival for Sinonasal Rhabdomyosarcoma

Objectives Literature detailing factors affecting survival in sinonasal rhabdomyosarcoma (SNRMS) is limited due to its rarity. We analyze the demographics, potential prognostic factors, overall survival, and treatment efficacy of SNRMS. Study Design and Setting Administrative database study. Methods...

Full description

Saved in:
Bibliographic Details
Published in:Otolaryngology-head and neck surgery 2017-07, Vol.157 (1), p.142-149
Main Authors: Unsal, Aykut A., Chung, Sei Yeon, Unsal, Aylin B., Baredes, Soly, Eloy, Jean Anderson
Format: Article
Language:English
Subjects:
Adult
Demography
disease‐specific survival
Female
Humans
Male
Paranasal Sinus Neoplasms - mortality
Paranasal Sinus Neoplasms - pathology
Paranasal Sinus Neoplasms - therapy
population based
Prognosis
rhabdomyosarcoma
Rhabdomyosarcoma - mortality
Rhabdomyosarcoma - pathology
Rhabdomyosarcoma - therapy
SEER
SEER Program
sinonasal cancer
sinonasal rhabdomyosarcoma
Surveillance Epidemiology and End Results
survival
Survival Rate
Treatment Outcome
United States
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives Literature detailing factors affecting survival in sinonasal rhabdomyosarcoma (SNRMS) is limited due to its rarity. We analyze the demographics, potential prognostic factors, overall survival, and treatment efficacy of SNRMS. Study Design and Setting Administrative database study. Methods SNRMS was queried in the SEER database (1973-2013; Surveillance, Epidemiology, and End Results). Data were analyzed for demographic and clinicopathologic trends. Kaplan-Meier model was utilized for assessing survival. Results A total of 286 cases of SNRMS were identified. The median age at diagnosis was 24.5 years, and the mean tumor size was 5.1 cm. Overall 5-, 10-, and 20-year disease-specific survival was 35.1%, 25.4%, and 12.0%, respectively. Regional lymph node involvement was present at diagnosis in more than half of cases (54.3%) and distant metastasis in 32.2% of cases. Alveolar rhabdomyosarcoma (54.9%) and embryonal rhabdomyosarcoma (23.8%) were the primary histologies. Alveolar-type SNRMS was more likely than the embryonal type to metastasize to distant sites (41.7% vs 24.1%), and it possessed poorer 5-year survival (29.2% vs 45.6%). Distant metastasis decreased 5-year survival from 35.1% to 3.8%, whereas lymph node involvement did not significantly affect survival. Patients
ISSN:0194-5998
1097-6817
DOI:10.1177/0194599817696292