Lack of antimicrobial efficacy of mecetronium etilsulfate in propanol-based hand rubs for surgical hand disinfection

Summary The aim of this study was to determine if mecetronium etilsulfate (MES) contributes to overall efficacy in surgical hand disinfection. Three blinded hand rubs (45% iso-propanol, 30% n-propanol) were applied for 1.5 min and compared with the EN 12791 reference procedure (crossover design). On...

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Bibliographic Details
Published in:The Journal of hospital infection 2017-06, Vol.96 (2), p.189-191
Main Author: Kampf, G
Format: Article
Language:English
Subjects:
2-Propanol - pharmacology
Cross-Over Studies
Disinfectants - pharmacology
Hand Disinfection - methods
Humans
Infectious Disease
Mecetronium etilsulfate
Quaternary Ammonium Compounds - pharmacology
Surgical hand disinfection
Sustained efficacy
Time Factors
Treatment Outcome
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Summary:Summary The aim of this study was to determine if mecetronium etilsulfate (MES) contributes to overall efficacy in surgical hand disinfection. Three blinded hand rubs (45% iso-propanol, 30% n-propanol) were applied for 1.5 min and compared with the EN 12791 reference procedure (crossover design). One commercial hand rub contained 0.2% MES, and the two other hand rubs were identical apart from 0.2% MES. None of the formulations had a log10 reduction after 3 h that was significantly better compared with the reference procedure [mean 1.72 (standard deviation 1.15)]. The antimicrobial contribution of MES in hand rubs is questionable.
ISSN:0195-6701
1532-2939
DOI:10.1016/j.jhin.2017.03.001