Arsenic and porphyrins

Background To evaluate the possible effect of inorganic arsenic (iAs) and of its species on the urinary excretion of porphyrin homologues. Methods Total porphyrins and their homologues (copro, penta, hexa, hepta, uroporphyrins) and arsenic species (trivalent and pentavalent As; monomethyl arsonic ac...

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Bibliographic Details
Published in:American journal of industrial medicine 2002-09, Vol.42 (3), p.180-187
Main Authors: Apostoli, P., Sarnico, M., Bavazzano, P., Bartoli, D.
Format: Article
Language:English
Subjects:
Adult
arsenic
Arsenic - adverse effects
Arsenic Poisoning - diagnosis
Arsenic Poisoning - etiology
Biological and medical sciences
Case-Control Studies
Chemical and industrial products toxicology. Toxic occupational diseases
Chemical Industry
Chromatography, High Pressure Liquid
Cohort Studies
early effect indicators
Environmental Monitoring
Female
Humans
individual susceptibility
Male
Maximum Allowable Concentration
Medical sciences
Metals and various inorganic compounds
Middle Aged
occupational exposure
Occupational Exposure - adverse effects
Occupational Exposure - analysis
Occupational Health
porphyrin homologues
Porphyrins - metabolism
Porphyrins - urine
Probability
Reference Values
Risk Assessment
speciation
Toxicology
Urinalysis
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Summary:Background To evaluate the possible effect of inorganic arsenic (iAs) and of its species on the urinary excretion of porphyrin homologues. Methods Total porphyrins and their homologues (copro, penta, hexa, hepta, uroporphyrins) and arsenic species (trivalent and pentavalent As; monomethyl arsonic acid; dimethyl arsinic acid; arsenobetaine) were measured respectively by HPLC and HPLC‐ICP MS in urine from 86 art glass workers exposed to iAs and from 54 controls. Results A significant increase in the excretion of penta and uroporphyrins was demonstrated for workers exposed to As; As3 was the species best correlated with urinary porphyrin excretion. Conclusions The increase of urinary excretion for some porphyrin homologues appears to be consistent with the inhibition by As of URO‐decarboxylase in the heme biosynthesis pathway. The determination of urinary porphyrin homologues could be useful to assess, on a group basis, some early effects of arsenic and to demonstrate possible individual susceptibility to the element. Am. J. Ind. Med. 42:180–187, 2002. © 2002 Wiley‐Liss, Inc.
ISSN:0271-3586
1097-0274
DOI:10.1002/ajim.10123