Polycyclic aromatic hydrocarbon-DNA adducts among rickshaw drivers in Dhaka City, Bangladesh

This paper describes findings from a recently completed study of polycyclic aromatic hydrocarbon (PAH) exposure among city dwellers of Dhaka, Bangladesh. We measured PAH-DNA adducts in white blood cells (WBCs) as a marker of environmental and occupational PAH exposure in 46 rickshaw drivers (who ped...

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Bibliographic Details
Published in:International archives of occupational and environmental health 2003-09, Vol.76 (7), p.533-538
Main Authors: HAFIZUR RAHMAN, M, ARSLAN, M. Iqbal, YU CHEN, ALI, Suhrab, PARVIN, Tanzeema, LIAN WEN WANG, SANTELLA, Regina M, AHSAN, Habibul
Format: Article
Language:English
Subjects:
Adult
Air
Aromatic hydrocarbons
Bangladesh
Biological and medical sciences
Case-Control Studies
Deoxyribonucleic acid
DNA
DNA Adducts - analysis
Environmental pollutants toxicology
Health risks
Humans
Hydrocarbons
Leukocytes
Male
Medical sciences
Occupational Exposure
Polycyclic aromatic hydrocarbons
Polycyclic Aromatic Hydrocarbons - analysis
Smoking
Toxicology
Transportation
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Summary:This paper describes findings from a recently completed study of polycyclic aromatic hydrocarbon (PAH) exposure among city dwellers of Dhaka, Bangladesh. We measured PAH-DNA adducts in white blood cells (WBCs) as a marker of environmental and occupational PAH exposure in 46 rickshaw drivers (who pedal commercial unshielded three-wheelers for passenger transport) and 48 non-rickshaw drivers (comparison group) in Dhaka city. We performed enzyme-linked immunosorbent assay (ELISA) to quantify immunologically the WBC PAH-DNA adducts. Rickshaw drivers had a significantly higher WBC PAH-DNA adducts level than the non-rickshaw drivers. Among rickshaw drivers, adduct levels tended to be positively associated with the duration of residence in the city and cigarette smoking. No such trends were observed among non-rickshaw drivers. In conclusion, the results suggest that urban residents who are occupationally exposed to traffic pollution in Dhaka are at potentially higher risk of health effects from exposure to carcinogenic PAH compounds.
ISSN:0340-0131
1432-1246
DOI:10.1007/s00420-003-0431-z