Double Dissociation of Function Within the Hippocampus: Spatial Memory and Hyponeophagia

Complete and dorsal hippocampal lesions impaired spatial performance on 2 working memory tasks: rewarded alternation on the T maze and matching to position in the water maze. In contrast, ventral hippocampal lesions had no effect on these tasks, even when task difficulty was increased by the introdu...

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Bibliographic Details
Published in:Behavioral neuroscience 2002-10, Vol.116 (5), p.884-901
Main Authors: Bannerman, D. M, Deacon, R. M. J, Offen, S, Friswell, J, Grubb, M, Rawlins, J. N. P
Format: Article
Language:English
Subjects:
Affectivity. Emotion
Amphetamine - pharmacology
Analysis of Variance
Anatomical correlates of behavior
Animal
Animal behavior
Animal Ethology
Animal Locomotion
Animal memory
Animals
Anxiety
Behavior, Animal
Behavioral psychophysiology
Biological and medical sciences
Brain
Brain Mapping
Central Nervous System Stimulants - pharmacology
Excitatory Amino Acid Agonists - toxicity
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Hippocampus
Hippocampus - injuries
Hippocampus - physiopathology
Hyperphagia - etiology
Learning. Memory
Locomotion - drug effects
Locomotion - physiology
Male
Maze Learning - physiology
Mazes
Memory
N-Methylaspartate - toxicity
Neurology
Personality. Affectivity
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Reaction Time
Rodents
Short Term Memory
Social Interaction
Space Perception - physiology
Spatial Memory
T Mazes
Time Factors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Citations: Items that this one cites
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Description
Summary:Complete and dorsal hippocampal lesions impaired spatial performance on 2 working memory tasks: rewarded alternation on the T maze and matching to position in the water maze. In contrast, ventral hippocampal lesions had no effect on these tasks, even when task difficulty was increased by the introduction of delays. Ventral lesions did resemble complete lesions in reducing anxiety in 3 commonly used tests of anxiety (social interaction, plus-maze, and hyponeophagia). Dorsal lesions also appeared to be anxiolytic in the social interaction and plus-maze tests, but they did not affect hyponeophagia. Complete- and dorsal-lesioned rats displayed hyperactivity, whereas ventral-lesioned rats did not. These results show a double dissociation between dorsal and ventral hippocampal lesions (hyponeophagia vs. spatial memory), suggesting differentiation of function along the septotemporal axis of this structure.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.116.5.884