Long-Term Estrogen Therapy Worsens the Behavioral and Neuropathological Consequences of Chronic Brain Inflammation

Alzheimer's disease (AD) is accompanied by chronic neuroinflammation and occurs with greater incidence in postmenopausal women. The increased incidence may be delayed by estrogen replacement therapy (ERT). The authors investigated the interaction of chronic ERT and lipopolysaccharide (LPS)-indu...

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Bibliographic Details
Published in:Behavioral neuroscience 2002-10, Vol.116 (5), p.902-911
Main Authors: Marriott, L. K, Hauss-Wegrzyniak, B, Benton, R. S, Vraniak, P. D, Wenk, G. L
Format: Article
Language:English
Subjects:
Alzheimer's Disease
Analysis of Variance
Animal
Animal memory
Animals
Antigens, Differentiation - drug effects
Antigens, Differentiation - metabolism
Behavior, Animal - drug effects
Behavioral psychophysiology
Biological and medical sciences
Brain Damage
Chronic Disease
Consequence
Drug Interactions
Encephalitis - etiology
Estrogen Replacement Therapy - adverse effects
Estrogens
Estrogens - pharmacology
Female
Fundamental and applied biological sciences. Psychology
Hormone replacement therapy
Hormone Therapy
Hormones and behavior
Lipopolysaccharides - toxicity
Longitudinal Studies
Maze Learning
Maze Learning - drug effects
Microglia - drug effects
Microglia - metabolism
Neurology
Ovariectomy
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Inbred F344
Rodents
Time Factors
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Summary:Alzheimer's disease (AD) is accompanied by chronic neuroinflammation and occurs with greater incidence in postmenopausal women. The increased incidence may be delayed by estrogen replacement therapy (ERT). The authors investigated the interaction of chronic ERT and lipopolysaccharide (LPS)-induced neuroinflammation in the female rat. Ovariectomy did not impair water maze performance; however, addition of chronic ERT or neuroinflammation resulted in an impairment that became exacerbated by the simultaneous occurrence of both conditions. Chronic LPS activated microglia, which was not reduced by ERT. Intact females receiving LPS infusion were not impaired in the water maze and had significantly fewer activated microglia. Results suggest that chronic ERT in postmenopausal women may exacerbate the memory impairment induced by the chronic neuroinflammation associated with AD.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.116.5.902