Polyphenol Supplementation Inhibits Physiological Increase of Prostaglandin E2 During Reproductive Period – A Randomized Clinical Trial

Abstract Anti-inflammatory property of polyphenols and their effect on the metabolism of prostaglandins is not established in healthy humans. This study aimed to evaluate the effect of polyphenol supplementation in plasma levels of prostaglandin E2 and other markers of inflammation and oxidative str...

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Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2018-09, Vol.136, p.77-83
Main Authors: Zilio, A.M, Zielinsky, P, Vian, I, Lampert, K, Raupp, D, Weschenfelder, C, Brum, C, Arnt, A, Piccoli, A, Nicoloso, L.H, Schaun, M.I, Markoski, M
Format: Article
Language:English
Subjects:
Advanced Basic Science
Endocrinology & Metabolism
Hormonal contraceptives
Inflammation
Polyphenols
Prostaglandin E2
Supplementation
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Summary:Abstract Anti-inflammatory property of polyphenols and their effect on the metabolism of prostaglandins is not established in healthy humans. This study aimed to evaluate the effect of polyphenol supplementation in plasma levels of prostaglandin E2 and other markers of inflammation and oxidative stress in women using contraceptives. In this randomized double-blind clinical trial, women aged 25 to 35 years were selected. Participants received capsules containing polyphenols or placebo, to be consumed for fifteen days. From 40 women randomized, 28 completed the study. Control group showed a significant increase in the levels of PGE2 ( p =0.01) while the polyphenols group showed no change in these levels ( p =0.79). There was an increase in hs-CRP ( p
ISSN:0952-3278
1532-2823
DOI:10.1016/j.plefa.2017.04.001