Factors influencing the post-exercise hepcidin-25 response in elite athletes

Purpose The extent to which hepcidin regulation after acute bouts of exercise is influenced by baseline (resting) concentrations of key iron parameters remains uncertain. This investigation explored the influence of selected iron parameters and 25-km race walk time on 3-h post-exercise hepcidin-25 l...

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Bibliographic Details
Published in:European journal of applied physiology 2017-06, Vol.117 (6), p.1233-1239
Main Authors: Peeling, Peter, McKay, Alannah K. A., Pyne, David B., Guelfi, Kym J., McCormick, Rachel H., Laarakkers, Coby M., Swinkels, Dorine W., Garvican-Lewis, Laura A., Ross, Megan L. R., Sharma, Avish P., Leckey, Jill J., Burke, Louise M.
Format: Article
Language:English
Subjects:
Adult
Athletes
Biomedical and Life Sciences
Biomedicine
Exercise
Ferritin
Hemoglobin
Hepcidin
Hepcidins - blood
Human Physiology
Humans
Interleukin 6
Interleukin-6 - blood
Iron
Iron - blood
Male
Multiple regression analysis
Occupational Medicine/Industrial Medicine
Original Article
Sports Medicine
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Summary:Purpose The extent to which hepcidin regulation after acute bouts of exercise is influenced by baseline (resting) concentrations of key iron parameters remains uncertain. This investigation explored the influence of selected iron parameters and 25-km race walk time on 3-h post-exercise hepcidin-25 levels in international-level race walkers. Methods Twenty-four male race walkers completed a graded exercise test and a 25-km race-walk trial. Throughout the 25-km race-walk, venous blood samples were collected pre-exercise, immediately post-exercise, and at 3-h post-exercise. Blood was analysed for serum ferritin, serum iron, Interleukin-6 (IL-6), and hepcidin-25 concentration. Results IL-6 and hepcidin-25 increased (7.6- and 7.5-fold, respectively) in response to the 25-km race-walk trial (both p   0.62; p  
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-017-3611-3