A comparative protein profiling of lymphocytes from blood of patients with chronic lymphoid leukemia by high-resolution mass-spectrometry in search of new markers for heterogeneity and disease prognosis

To find new markers of chronic lymphoid leukemia heterogeneity, a comparison of the proteomic profiles of pathologic and healthy lymphocytes from blood was carried out by high-resolution mass spectrometry and label-free quantitative analysis. A list of the most typical proteins for the two groups wa...

Full description

Saved in:
Bibliographic Details
Published in:Journal of analytical chemistry (New York, N.Y.) N.Y.), 2016-12, Vol.71 (13), p.1242-1250
Main Authors: Glazyrin, Yu. E., Komarova, M. A., Bakhtina, V. I., Silacheva, M. V., Demko, I. V., Zamay, A. S., Zamay, T. N.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Care and treatment
Chemistry
Chemistry and Materials Science
Comparative analysis
Diagnosis
Heterogeneity
Heterogeneous catalysis
High resolution
Leukemia
Lymphocytes
Markers
Mass spectrometry
Prognosis
Proteins
Quantitative analysis
Scientific imaging
Spectroscopy
Statistical analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To find new markers of chronic lymphoid leukemia heterogeneity, a comparison of the proteomic profiles of pathologic and healthy lymphocytes from blood was carried out by high-resolution mass spectrometry and label-free quantitative analysis. A list of the most typical proteins for the two groups was obtained. The differences in the proteomic profiles within the pathologic group, which were consistent with the heterogeneity of clinical background, were found. Two subsets within the area of the pathologic cells were formed using statistical analysis; the list of characteristic proteins for each subset was obtained.
ISSN:1061-9348
1608-3199
DOI:10.1134/S1061934816130062