Therapeutic Inhibition of Complement: Well Worth the Risk

Complement is an integral part of the immune system and protects against infection. Complement-mediated immunopathology in many autoimmune diseases and syndromes has led to the therapeutic targeting of complement and to questions around the safety of complement inhibition. Here; I examine and clarif...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2017-06, Vol.38 (6), p.503-505
Main Author: Barnum, Scott R
Format: Article
Language:English
Subjects:
Advanced Basic Science
alternative pathway
complement
Complement Inactivating Agents - adverse effects
Complement Inactivating Agents - pharmacology
Complement Pathway, Alternative - drug effects
Complement Pathway, Alternative - immunology
Complement System Proteins - immunology
Humans
membrane attack complex
meningococcal disease
Risk Assessment
terminal pathway
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Summary:Complement is an integral part of the immune system and protects against infection. Complement-mediated immunopathology in many autoimmune diseases and syndromes has led to the therapeutic targeting of complement and to questions around the safety of complement inhibition. Here; I examine and clarify the risks associated with complement therapeutics.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2017.03.009