Overdose Risk in Young Children of Women Prescribed Opioids

Over the past 20 years, the prescribing of opioids has increased dramatically in North America, with parallel increases in opioid addiction, overdose, and associated deaths. We examined whether young children of women prescribed opioids were at increased risk of opioid overdose. We conducted a popul...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2017-03, Vol.139 (3), p.1-1
Main Authors: Finkelstein, Yaron, Macdonald, Erin M, Gonzalez, Alejandro, Sivilotti, Marco L A, Mamdani, Muhammad M, Juurlink, David N
Format: Article
Language:English
Subjects:
Accidents, Home - statistics & numerical data
Analgesics, Opioid - adverse effects
Analysis
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Antidepressive Agents - therapeutic use
Case-Control Studies
Child, Preschool
Children & youth
Codeine - adverse effects
Drug addiction
Drug overdose
Drug Overdose - epidemiology
Drugs
Female
Health aspects
Hospitalization - statistics & numerical data
Humans
Infant
Male
Methadone - adverse effects
Mothers
Narcotics
Ontario
Opioids
Overdose
Oxycodone - adverse effects
Pediatrics
Prescribing
Prescription Drugs - adverse effects
Prescriptions (Drugs)
Risk factors
Teenagers
Youth
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Summary:Over the past 20 years, the prescribing of opioids has increased dramatically in North America, with parallel increases in opioid addiction, overdose, and associated deaths. We examined whether young children of women prescribed opioids were at increased risk of opioid overdose. We conducted a population-based, nested case control study in Ontario, Canada, between 2002 and 2015. We identified children aged ≤10 years, whose mothers received publicly funded prescriptions for an opioid or a nonsteroidal antiinflammatory drug (comparator analgesic) in the preceding year. Cases were children who presented to hospital for or died of opioid overdose. Each case was matched with 4 controls with no opioid overdose. The primary outcome was the risk of opioid overdose. We identified 103 children who presented to the hospital with opioid overdose and matched them with 412 controls. Half of the children with opioid overdose were
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2016-2887