Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individuals

Alkylglycerols (AKGs), isolated or present in shark liver oil have anti-inflammatory properties. Complement 3 (C3) and 4 (C4) participate in lipid metabolism and in obesity, contributing to the metabolic syndrome and to the low-grade inflammation associated with obesity. In a randomized, controlled,...

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Bibliographic Details
Published in:Inflammopharmacology 2016-06, Vol.24 (2-3), p.127-131
Main Authors: Parri, A., Fitó, Montserrat, Torres, C. F., Muñoz-Aguayo, D., Schröder, H., Cano, J. F., Vázquez, L., Reglero, G., Covas, María-Isabel
Format: Article
Language:English
Subjects:
Adult
Allergology
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - isolation & purification
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Cross-Over Studies
Dermatology
Double-Blind Method
Female
Fish Oils - administration & dosage
Fish Oils - isolation & purification
Gastroenterology
Glycerol - administration & dosage
Glycerol - isolation & purification
Humans
Immunology
Male
Middle Aged
Obesity - blood
Obesity - diagnosis
Obesity - diet therapy
Pharmacology/Toxicology
Pilot Projects
Rheumatology
Short Communication
Vascular Endothelial Growth Factor A - antagonists & inhibitors
Vascular Endothelial Growth Factor A - blood
Young Adult
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Summary:Alkylglycerols (AKGs), isolated or present in shark liver oil have anti-inflammatory properties. Complement 3 (C3) and 4 (C4) participate in lipid metabolism and in obesity, contributing to the metabolic syndrome and to the low-grade inflammation associated with obesity. In a randomized, controlled, crossover study, 26 non-diabetes obese individuals were assigned two preparations with low (LAC, 10 mg AKGs) and high (HAC, 20 mg AKGs) AKG content. Intervention periods were of 3 weeks preceded by 2-week washout periods in which shark liver oil was avoided. Cholesterol, C3, C4, and vascular endothelial growth factor (VEGF) decreased in a linear trend ( P  
ISSN:0925-4692
1568-5608
DOI:10.1007/s10787-016-0265-4