Relation of Stroke and Major Bleeding to Creatinine Clearance in Patients With Atrial Fibrillation (From the Fushimi AF Registry)

Abstract Creatinine clearance (CrCl) has been widely used to adjust the dosage of non-vitamin K antagonist oral anticoagulants in atrial fibrillation (AF) patients and exclude contraindicated patients. However, there are few available real-world data on the relationship between CrCl and adverse clin...

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Bibliographic Details
Published in:The American journal of cardiology 2017-04, Vol.119 (8), p.1229-1237
Main Authors: Abe, Mitsuru, MD, PhD, Ogawa, Hisashi, MD, Ishii, Mitsuru, MD, Masunaga, Nobutoyo, MD, Esato, Masahiro, MD, PhD, Chun, Yeong-Hwa, MD, PhD, Tsuji, Hikari, MD, PhD, Wada, Hiromichi, MD, PhD, Hasegawa, Koji, MD, PhD, Lip, Gregory Y.H., MD, Akao, Masaharu, MD, PhD
Format: Article
Language:English
Subjects:
Age
Aged
Alcoholic beverages
Anticoagulants
Atrial Fibrillation - epidemiology
Bleeding
Body weight
Brain
Cardiac arrhythmia
Cardiovascular
Cerebral blood flow
Cerebral infarction
Chest
Classification
Clinical outcomes
Clinical trials
Cohort Studies
Committees
Computed tomography
Congestive heart failure
Creatinine
Creatinine - analysis
Death
Diabetes mellitus
Diagnosis
Documentation
Dosage
Drug abuse
Drugs
EKG
Embolism - epidemiology
Enrollments
Female
Filtration
Gender
Health hazards
Health risks
Heart
Heart attacks
Heart failure
Heart Failure - epidemiology
Hemodialysis
Hemoglobin
Hemorrhage - epidemiology
Hospitalization
Humans
Hypertension
Incidence
Intervention
Ischemia
Japan - epidemiology
Liver
Magnetic resonance imaging
Male
Mathematical models
Mortality
Myocardial infarction
Myocardial Infarction - epidemiology
Neuroimaging
Population density
Predictions
Registries
Renal function
Risk
Risk factors
Statistical tests
Stroke
Stroke - epidemiology
Thromboembolism
Thrombosis
Transfusion
Warfarin
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Description
Summary:Abstract Creatinine clearance (CrCl) has been widely used to adjust the dosage of non-vitamin K antagonist oral anticoagulants in atrial fibrillation (AF) patients and exclude contraindicated patients. However, there are few available real-world data on the relationship between CrCl and adverse clinical outcomes in AF patients. Therefore, we evaluated the clinical characteristics and adverse events in Japanese AF patients stratified by CrCl. We categorized patients in the Fushimi AF Registry, a large prospective community-based Japanese cohort of AF patients, into three groups as follows: (i) CrCl
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2017.01.005