Prescribing in schizophrenia and psychosis: Increasing polypharmacy over time

Introduction Diabetes, obesity, and metabolic syndrome are highly prevalent in patients with severe mental illness. Psychotropic polypharmacy is becoming increasingly prevalent within the UK. We determined the change in the number of psychotropic medications prescribed over time and trends in weight...

Full description

Saved in:
Bibliographic Details
Published in:Human psychopharmacology 2017-03, Vol.32 (2), p.e2579-n/a
Main Authors: Heald, Adrian, Livingston, Mark, Yung, Alison, De Hert, M.A.
Format: Article
Language:English
Subjects:
Antipsychotics
Blood glucose
Blood Glucose - drug effects
BMI
Body mass
Body Mass Index
Clozapine
Diabetes mellitus
Fasting
Female
Glucose
Humans
Male
Mental disorders
Metabolic syndrome
Polypharmacy
Practice Patterns, Physicians' - trends
prescribing
Psychosis
Psychotic Disorders - complications
Psychotic Disorders - drug therapy
psychotropic
Psychotropic Drugs - therapeutic use
Registers
Registries - statistics & numerical data
Schizophrenia
Schizophrenia - complications
Schizophrenia - drug therapy
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Diabetes, obesity, and metabolic syndrome are highly prevalent in patients with severe mental illness. Psychotropic polypharmacy is becoming increasingly prevalent within the UK. We determined the change in the number of psychotropic medications prescribed over time and trends in weight and fasting blood glucose. Methods One hundred ninety‐five individuals with schizophrenia and psychosis on the Severe Mental Illness Register in Cheshire, UK, were followed up between 2004 and 2012. Individuals were identified through a semianonymised search of general practitioner registers. Results The total number of different medications prescribed increased from 140 in 2004 to 226 in 2012 with the mean number of medication groups per patient increasing from 0.71 to 1.15 (p 
ISSN:0885-6222
1099-1077
DOI:10.1002/hup.2579