Unveil the mysterious mask of cytokine-based immunotherapy for melanoma

Abstract Melanoma is the leading cause of death among all skin cancers and its incidence continues to rise rapidly worldwide in the past decades. The available treatment options for melanoma remain limited despite extensive clinical research. Melanoma is an immunogenic tumor and great advances in im...

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Bibliographic Details
Published in:Cancer letters 2017-05, Vol.394, p.43-51
Main Authors: Xu, Dixon H, Zhu, Ziwen, Xiao, Huaping, Wakefield, Mark R, Bai, Qian, Nicholl, Michael B, Ding, Vivi A, Fang, Yujiang
Format: Article
Language:English
Subjects:
Animals
Antigens
Antineoplastic Agents - immunology
Antineoplastic Agents - metabolism
Antineoplastic Agents - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cancer therapies
Chemotherapy
Cytokine
Cytokines
Cytokines - immunology
Cytokines - metabolism
Cytokines - therapeutic use
Hematology, Oncology and Palliative Medicine
Humans
Immunogenicity
Immunology
Immunotherapy
Immunotherapy - methods
Incidence
Interferon
Lymphocytes
Medical prognosis
Melanoma
Melanoma - drug therapy
Melanoma - immunology
Melanoma - metabolism
Melanoma - pathology
Metastasis
Molecular Targeted Therapy
Oncology
Signal Transduction - drug effects
Skin cancer
Skin Neoplasms - drug therapy
Skin Neoplasms - immunology
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
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Summary:Abstract Melanoma is the leading cause of death among all skin cancers and its incidence continues to rise rapidly worldwide in the past decades. The available treatment options for melanoma remain limited despite extensive clinical research. Melanoma is an immunogenic tumor and great advances in immunology in recent decades allow for the development of immunotherapeutic agents against melanoma. In recent years, immunotherapy utilizing cytokines has been particularly successful in certain cancers and holds promise for patients with advanced melanoma. In this review, an overview of the current status and emerging perspectives on cytokine immunotherapy for melanoma are discussed in details. Such a study will be helpful to unveil the mysterious mask of cytokine-based immunotherapy for melanoma.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2017.02.022