Leveraging Stem Cell Homing for Therapeutic Regeneration

Resident stem cell pools in many tissues/organs are responsible not only for tissue maintenance during physiologic turnover but also for the process of wound repair following injury. With inspiration from stem cell trafficking within the body under physiologic and pathologic conditions, recent advan...

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Bibliographic Details
Published in:Journal of Dental Research 2017-06, Vol.96 (6), p.601-609
Main Authors: Yin, Y., Li, X., He, X.T., Wu, R.X., Sun, H.H., Chen, F.M.
Format: Article
Language:English
Subjects:
Animals
Biomaterials
Biomedical materials
Bone marrow
Cell Movement - physiology
Cell Transdifferentiation - physiology
Dentistry
Engineers
Growth factors
Hematopoietic Stem Cell Mobilization - methods
Humans
Regeneration
Regeneration - physiology
Stem Cell Niche
Stem Cell Transplantation - methods
Stem cells
Stem Cells - physiology
Therapeutic applications
Tissue engineering
Translational Medical Research
Transplantation
Wound healing
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Summary:Resident stem cell pools in many tissues/organs are responsible not only for tissue maintenance during physiologic turnover but also for the process of wound repair following injury. With inspiration from stem cell trafficking within the body under physiologic and pathologic conditions, recent advances have been made toward inducing stem cell mobilization and directing patients’ own cells to sites of interest for treating a broad spectrum of diseases. An evolving body of work corroborates that delivering guidance cues can mobilize stem cells from the bone marrow and drive these cells toward a specific region. In addition, the transplantation of cell-friendly biomaterials incorporating certain biomolecules has led to the regeneration of lost/damaged tissue without the need for delivering cellular materials manipulated ex vivo. Recently, cell homing has resulted in remarkable biological discoveries in the laboratory as well as great curative successes in preclinical scenarios. Here, we review the biological evidence underlying in vivo cell mobilization and homing with the aim of leveraging endogenous reparative cells for therapeutic applications. Considering both the promise and the obstacles of this approach, we discuss how matrix components of the in vivo milieu can be modified to promote the native regenerative process and inspire future tissue-engineering design.
ISSN:0022-0345
1544-0591
DOI:10.1177/0022034517706070