Changes in peripheral blood T-cell balance after percutaneous tumor ablation

Purpose: To evaluate the changes in T-cell balance in peripheral blood following percutaneous tumor ablation. Material and methods: Patients underwent thermal ablation including radiofrequency (n = 9) and microwave ablation (n = 5), or cryoablation (n = 5). Target tumors were located in the lung (n ...

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Bibliographic Details
Published in:Minimally invasive therapy and allied technologies 2017-11, Vol.26 (6), p.331-337
Main Authors: Takaki, Haruyuki, Imai, Naoko, Thomas, Contessa T., Yamakado, Koichiro, Yarmohammadi, Hooman, Ziv, Etay, Srimathveeravalli, Govindarajan, Sofocleous, Constantinos T., Solomon, Stephen B., Erinjeri, Joseph P.
Format: Article
Language:English
Subjects:
cryoablation
lymphocyte
microwave ablation
Radiofrequency ablation
T-cell
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Summary:Purpose: To evaluate the changes in T-cell balance in peripheral blood following percutaneous tumor ablation. Material and methods: Patients underwent thermal ablation including radiofrequency (n = 9) and microwave ablation (n = 5), or cryoablation (n = 5). Target tumors were located in the lung (n = 7), soft tissue (n = 5), liver (n = 4), and bone (n = 3). Patient peripheral blood samples were collected before and within 14 days after ablation. Peripheral blood populations of cytotoxic T-cells (CTL), type-1 (T h 1) and type-2 helper T-cells (T h 2), and regulatory T-cells (T reg ) were measured using flow cytometry. Changes in CTL/T reg and T h 1/T h 2 ratios before and after ablation therapy were compared using paired t-tests. Results: Peripheral blood CTL population (27.5 ± 2.1% to 30.2 ± 2.5%, p 
ISSN:1364-5706
1365-2931
DOI:10.1080/13645706.2017.1310737