Osteoinductive composite coatings for flexible intramedullary nails

• Published in: Materials Science & Engineering C 2017-06, Vol.75, p.207-220
• Main Authors: Bolbasov, E.N., Popkov, A.V., Popkov, D.A., Gorbach, E.N., Khlusov, I.A., Golovkin, A.S., Sinev, A., Bouznik, V.M., Tverdokhlebov, S.I., Anissimov, Y.G.
• Format: Article
• Language: English
• Subjects: Adhesive bonding; Adhesive strength; Animals; Biocompatibility; Biological effects; Biological properties; Bonding strength; Bone Nails; Bone Regeneration; Bones; Calcium; Calcium phosphates; Coated Materials, Biocompatible - chemistry; Coatings; Comparative studies; Copolymers; Crystallization; Dogs; Durapatite - chemistry; Elongation; Female; Fins; Flexible intramedullary nail; Fluorides; Fluorocarbons - chemistry; Humans; Hydroxyapatite; Intramedullary nails; Male; Materials science; Materials Testing; Nails; Osteogenesis; Oxidation; Phosphate coatings; Phosphates; Physicochemical properties; Piezoelectric; Piezoelectricity; Surgical implants; Tetrafluoroethylene; Vinyl Compounds - chemistry; Vinylidene; Vinylidene fluoride; Vinylidene fluoride − tetrafluoroethylene copolymer
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2017.02.073

This work presents composite coatings based on a copolymer of vinylidene fluoride with tetrafluoroethylene (VDF-TeFE) and hydroxyapatite (HA) for flexible intramedullary nails (FIN). The effect of the proportion of VDF-TeFE (100–25% wt.) on physicochemical and biological properties of the composite coatings was investigated. It was shown that a decrease of VDF-TeFE in the coating hinders its crystallization in β and γ forms which have piezoelectric properties. The decrease also reduces an adhesive strength to 9.9±2.4MPa and a relative elongation to 5.9±1.2%, but results in increased osteogenesis. It was demonstrated that the composite coatings with 35% VDF-TeFE has the required combination of physicochemical properties and osteogenic activity. Comparative studies of composite coatings (35% VDF-TeFE) and calcium phosphate coatings produced using micro-arc oxidation, demonstrated comparable results for strength of bonding of these FINs with trabecular bones (~530MPa). It was hypothesized that the high osteoinductive properties of the composite coatings are due to their piezoelectric properties. [Display omitted] •VDF-TeFE copolymer/HA composite coatings for flexible intramedullary nail were designed.•The influence of the amount of VDF-TeFE on properties of composites was studied.•VDF-TeFE has electrical activity phases regardless of its content in the composite.•Osteoinductive properties, likely is caused by piezoelectric properties of the composite.