Coronary Atherosclerotic Plaque Characteristics and Cardiovascular Risk Factors　― Insights From an Optical Coherence Tomography Study

Background:The association between cardiovascular risk factors (CVRF) and the risk of coronary events is widely acknowledged. Whether individual risk factors may be associated with distinct plaque characteristics is currently unclear. We investigated the relationship between CVRF and coronary plaque...

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Bibliographic Details
Published in:Circulation Journal 2017/07/25, Vol.81(8), pp.1165-1173
Main Authors: Rosa, Roberta De, Vasa-Nicotera, Mariuca, Leistner, David M., Reis, Sophia M., Thome, Claudia E., Boeckel, Jes-Niels, Fichtlscherer, Stephan, Zeiher, Andreas M.
Format: Article
Language:English
Subjects:
Aged
Cardiovascular risk factors
Coronary artery disease
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - etiology
Diabetes Complications - diagnostic imaging
Female
Humans
Male
Middle Aged
Obesity - complications
Obesity - diagnostic imaging
Optical coherence tomography
Plaque erosion
Plaque, Atherosclerotic - diagnostic imaging
Plaque, Atherosclerotic - etiology
Prediabetic State - complications
Prediabetic State - diagnostic imaging
Registries
Tomography, Optical Coherence
Vulnerable plaque
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Summary:Background:The association between cardiovascular risk factors (CVRF) and the risk of coronary events is widely acknowledged. Whether individual risk factors may be associated with distinct plaque characteristics is currently unclear. We investigated the relationship between CVRF and coronary plaque burden and phenotype.Methods and Results:We assessed coronary atherosclerotic plaque characteristics by optical coherence tomography in 67 patients with stable coronary artery disease undergoing coronary angiography. The plaque burden and the distinct plaque phenotypes were compared with regard to different CVRF. Overall plaque burden was significantly greater in patients with diabetes mellitus (P=0.010), prediabetes (P=0.035) and obesity (P=0.024), and correlated with the number of CVRF (R=0.358, P=0.003). Patients with diabetes had a greater extent of fibroatheroma (P=0.015), calcific fibroatheroma (P=0.031), thin-cap fibroatheroma (TCFA-P=0.011) and plaque erosion (P=0.002). Obese patients showed a greater extent of fibroatheroma (P=0.007), TCFA (P=0.015) and macrophage load (P=0.043). The number of CVRF correlated with fibroatheroma (R=0.425, P
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-17-0054