Loading…
Coronary Atherosclerotic Plaque Characteristics and Cardiovascular Risk Factors ― Insights From an Optical Coherence Tomography Study
Background:The association between cardiovascular risk factors (CVRF) and the risk of coronary events is widely acknowledged. Whether individual risk factors may be associated with distinct plaque characteristics is currently unclear. We investigated the relationship between CVRF and coronary plaque...
Saved in:
| Published in: | Circulation Journal 2017/07/25, Vol.81(8), pp.1165-1173 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c622t-1ea2d5e7a19a0fc4a8a37a424ff4fee71a41ebb1078e5757d439d3b09335da693 |
|---|---|
| cites | |
| container_end_page | 1173 |
| container_issue | 8 |
| container_start_page | 1165 |
| container_title | Circulation Journal |
| container_volume | 81 |
| creator | Rosa, Roberta De Vasa-Nicotera, Mariuca Leistner, David M. Reis, Sophia M. Thome, Claudia E. Boeckel, Jes-Niels Fichtlscherer, Stephan Zeiher, Andreas M. |
| description | Background:The association between cardiovascular risk factors (CVRF) and the risk of coronary events is widely acknowledged. Whether individual risk factors may be associated with distinct plaque characteristics is currently unclear. We investigated the relationship between CVRF and coronary plaque burden and phenotype.Methods and Results:We assessed coronary atherosclerotic plaque characteristics by optical coherence tomography in 67 patients with stable coronary artery disease undergoing coronary angiography. The plaque burden and the distinct plaque phenotypes were compared with regard to different CVRF. Overall plaque burden was significantly greater in patients with diabetes mellitus (P=0.010), prediabetes (P=0.035) and obesity (P=0.024), and correlated with the number of CVRF (R=0.358, P=0.003). Patients with diabetes had a greater extent of fibroatheroma (P=0.015), calcific fibroatheroma (P=0.031), thin-cap fibroatheroma (TCFA-P=0.011) and plaque erosion (P=0.002). Obese patients showed a greater extent of fibroatheroma (P=0.007), TCFA (P=0.015) and macrophage load (P=0.043). The number of CVRF correlated with fibroatheroma (R=0.425, P |
| doi_str_mv | 10.1253/circj.CJ-17-0054 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1889765274</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1889765274</sourcerecordid><originalsourceid>FETCH-LOGICAL-c622t-1ea2d5e7a19a0fc4a8a37a424ff4fee71a41ebb1078e5757d439d3b09335da693</originalsourceid><addsrcrecordid>eNpFkb1u2zAUhYmiRf6avVPBsYtS_kmkxkCo2wQBUiTpTFxTV7ZcSXRJKYA3r32AvmD6IqVjN1kuCeI754LnEPKBswsucvnZtcGtLqrrjOuMsVy9ISdcKp0pI9jb53uRlUbJY3Ia44oxUbK8PCLHwijBDC9OyO_KBz9A2NDLcYnBR9elObaOfu_g14S0WkIAN2JoY3qNFIaaVhDq1j9CdFMHgd618SedJciH-He7fdr-oVdDbBfLMdJZ8H3S0Nt1UkNHK5-24OCQPvjeLwKslxt6P0715j1510AX8fxwnpEfsy8P1bfs5vbrVXV5k7lCiDHjCKLOUQMvgTVOgQGpQQnVNKpB1BwUx_mcM20w17mulSxrOWellHkNRSnPyKe97zr49ME42r6NDrsOBvRTtNyYUhe50CqhbI-6FEwM2Nh1aPsUluXM7gqwzwXY6tpybXcFJMnHg_s077F-EfxPPAGzPbCKIyzwBYCQAurw4Gi4Nbvx6vwKpEIsDvIfri-goA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1889765274</pqid></control><display><type>article</type><title>Coronary Atherosclerotic Plaque Characteristics and Cardiovascular Risk Factors ― Insights From an Optical Coherence Tomography Study</title><source>Freely Accessible Journals</source><creator>Rosa, Roberta De ; Vasa-Nicotera, Mariuca ; Leistner, David M. ; Reis, Sophia M. ; Thome, Claudia E. ; Boeckel, Jes-Niels ; Fichtlscherer, Stephan ; Zeiher, Andreas M.</creator><creatorcontrib>Rosa, Roberta De ; Vasa-Nicotera, Mariuca ; Leistner, David M. ; Reis, Sophia M. ; Thome, Claudia E. ; Boeckel, Jes-Niels ; Fichtlscherer, Stephan ; Zeiher, Andreas M.</creatorcontrib><description>Background:The association between cardiovascular risk factors (CVRF) and the risk of coronary events is widely acknowledged. Whether individual risk factors may be associated with distinct plaque characteristics is currently unclear. We investigated the relationship between CVRF and coronary plaque burden and phenotype.Methods and Results:We assessed coronary atherosclerotic plaque characteristics by optical coherence tomography in 67 patients with stable coronary artery disease undergoing coronary angiography. The plaque burden and the distinct plaque phenotypes were compared with regard to different CVRF. Overall plaque burden was significantly greater in patients with diabetes mellitus (P=0.010), prediabetes (P=0.035) and obesity (P=0.024), and correlated with the number of CVRF (R=0.358, P=0.003). Patients with diabetes had a greater extent of fibroatheroma (P=0.015), calcific fibroatheroma (P=0.031), thin-cap fibroatheroma (TCFA-P=0.011) and plaque erosion (P=0.002). Obese patients showed a greater extent of fibroatheroma (P=0.007), TCFA (P=0.015) and macrophage load (P=0.043). The number of CVRF correlated with fibroatheroma (R=0.425, P<0.001), calcific fibroatheroma (R=0.321, P=0.008), TCFA (R=0.347, P=0.004), macrophage load (R=0.314, P=0.010) and erosion (R=0.271, P=0.029). In the multivariate analysis, altered glycemic status and obesity were the only independent predictors of TCFA (P=0.026 and P=0.046, respectively), whereas altered glycemic status was the only independent predictor of plaque erosion (P=0.001).Conclusions:Patients with diabetes, prediabetes and obesity show more extensive coronary atherosclerosis and more vulnerable plaque phenotypes.</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-17-0054</identifier><identifier>PMID: 28420816</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Aged ; Cardiovascular risk factors ; Coronary artery disease ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - etiology ; Diabetes Complications - diagnostic imaging ; Female ; Humans ; Male ; Middle Aged ; Obesity - complications ; Obesity - diagnostic imaging ; Optical coherence tomography ; Plaque erosion ; Plaque, Atherosclerotic - diagnostic imaging ; Plaque, Atherosclerotic - etiology ; Prediabetic State - complications ; Prediabetic State - diagnostic imaging ; Registries ; Tomography, Optical Coherence ; Vulnerable plaque</subject><ispartof>Circulation Journal, 2017/07/25, Vol.81(8), pp.1165-1173</ispartof><rights>2017 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c622t-1ea2d5e7a19a0fc4a8a37a424ff4fee71a41ebb1078e5757d439d3b09335da693</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4021,27921,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28420816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosa, Roberta De</creatorcontrib><creatorcontrib>Vasa-Nicotera, Mariuca</creatorcontrib><creatorcontrib>Leistner, David M.</creatorcontrib><creatorcontrib>Reis, Sophia M.</creatorcontrib><creatorcontrib>Thome, Claudia E.</creatorcontrib><creatorcontrib>Boeckel, Jes-Niels</creatorcontrib><creatorcontrib>Fichtlscherer, Stephan</creatorcontrib><creatorcontrib>Zeiher, Andreas M.</creatorcontrib><title>Coronary Atherosclerotic Plaque Characteristics and Cardiovascular Risk Factors ― Insights From an Optical Coherence Tomography Study</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background:The association between cardiovascular risk factors (CVRF) and the risk of coronary events is widely acknowledged. Whether individual risk factors may be associated with distinct plaque characteristics is currently unclear. We investigated the relationship between CVRF and coronary plaque burden and phenotype.Methods and Results:We assessed coronary atherosclerotic plaque characteristics by optical coherence tomography in 67 patients with stable coronary artery disease undergoing coronary angiography. The plaque burden and the distinct plaque phenotypes were compared with regard to different CVRF. Overall plaque burden was significantly greater in patients with diabetes mellitus (P=0.010), prediabetes (P=0.035) and obesity (P=0.024), and correlated with the number of CVRF (R=0.358, P=0.003). Patients with diabetes had a greater extent of fibroatheroma (P=0.015), calcific fibroatheroma (P=0.031), thin-cap fibroatheroma (TCFA-P=0.011) and plaque erosion (P=0.002). Obese patients showed a greater extent of fibroatheroma (P=0.007), TCFA (P=0.015) and macrophage load (P=0.043). The number of CVRF correlated with fibroatheroma (R=0.425, P<0.001), calcific fibroatheroma (R=0.321, P=0.008), TCFA (R=0.347, P=0.004), macrophage load (R=0.314, P=0.010) and erosion (R=0.271, P=0.029). In the multivariate analysis, altered glycemic status and obesity were the only independent predictors of TCFA (P=0.026 and P=0.046, respectively), whereas altered glycemic status was the only independent predictor of plaque erosion (P=0.001).Conclusions:Patients with diabetes, prediabetes and obesity show more extensive coronary atherosclerosis and more vulnerable plaque phenotypes.</description><subject>Aged</subject><subject>Cardiovascular risk factors</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - etiology</subject><subject>Diabetes Complications - diagnostic imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - complications</subject><subject>Obesity - diagnostic imaging</subject><subject>Optical coherence tomography</subject><subject>Plaque erosion</subject><subject>Plaque, Atherosclerotic - diagnostic imaging</subject><subject>Plaque, Atherosclerotic - etiology</subject><subject>Prediabetic State - complications</subject><subject>Prediabetic State - diagnostic imaging</subject><subject>Registries</subject><subject>Tomography, Optical Coherence</subject><subject>Vulnerable plaque</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpFkb1u2zAUhYmiRf6avVPBsYtS_kmkxkCo2wQBUiTpTFxTV7ZcSXRJKYA3r32AvmD6IqVjN1kuCeI754LnEPKBswsucvnZtcGtLqrrjOuMsVy9ISdcKp0pI9jb53uRlUbJY3Ia44oxUbK8PCLHwijBDC9OyO_KBz9A2NDLcYnBR9elObaOfu_g14S0WkIAN2JoY3qNFIaaVhDq1j9CdFMHgd618SedJciH-He7fdr-oVdDbBfLMdJZ8H3S0Nt1UkNHK5-24OCQPvjeLwKslxt6P0715j1510AX8fxwnpEfsy8P1bfs5vbrVXV5k7lCiDHjCKLOUQMvgTVOgQGpQQnVNKpB1BwUx_mcM20w17mulSxrOWellHkNRSnPyKe97zr49ME42r6NDrsOBvRTtNyYUhe50CqhbI-6FEwM2Nh1aPsUluXM7gqwzwXY6tpybXcFJMnHg_s077F-EfxPPAGzPbCKIyzwBYCQAurw4Gi4Nbvx6vwKpEIsDvIfri-goA</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Rosa, Roberta De</creator><creator>Vasa-Nicotera, Mariuca</creator><creator>Leistner, David M.</creator><creator>Reis, Sophia M.</creator><creator>Thome, Claudia E.</creator><creator>Boeckel, Jes-Niels</creator><creator>Fichtlscherer, Stephan</creator><creator>Zeiher, Andreas M.</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>Coronary Atherosclerotic Plaque Characteristics and Cardiovascular Risk Factors ― Insights From an Optical Coherence Tomography Study</title><author>Rosa, Roberta De ; Vasa-Nicotera, Mariuca ; Leistner, David M. ; Reis, Sophia M. ; Thome, Claudia E. ; Boeckel, Jes-Niels ; Fichtlscherer, Stephan ; Zeiher, Andreas M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c622t-1ea2d5e7a19a0fc4a8a37a424ff4fee71a41ebb1078e5757d439d3b09335da693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Cardiovascular risk factors</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - etiology</topic><topic>Diabetes Complications - diagnostic imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - complications</topic><topic>Obesity - diagnostic imaging</topic><topic>Optical coherence tomography</topic><topic>Plaque erosion</topic><topic>Plaque, Atherosclerotic - diagnostic imaging</topic><topic>Plaque, Atherosclerotic - etiology</topic><topic>Prediabetic State - complications</topic><topic>Prediabetic State - diagnostic imaging</topic><topic>Registries</topic><topic>Tomography, Optical Coherence</topic><topic>Vulnerable plaque</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosa, Roberta De</creatorcontrib><creatorcontrib>Vasa-Nicotera, Mariuca</creatorcontrib><creatorcontrib>Leistner, David M.</creatorcontrib><creatorcontrib>Reis, Sophia M.</creatorcontrib><creatorcontrib>Thome, Claudia E.</creatorcontrib><creatorcontrib>Boeckel, Jes-Niels</creatorcontrib><creatorcontrib>Fichtlscherer, Stephan</creatorcontrib><creatorcontrib>Zeiher, Andreas M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosa, Roberta De</au><au>Vasa-Nicotera, Mariuca</au><au>Leistner, David M.</au><au>Reis, Sophia M.</au><au>Thome, Claudia E.</au><au>Boeckel, Jes-Niels</au><au>Fichtlscherer, Stephan</au><au>Zeiher, Andreas M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronary Atherosclerotic Plaque Characteristics and Cardiovascular Risk Factors ― Insights From an Optical Coherence Tomography Study</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2017</date><risdate>2017</risdate><volume>81</volume><issue>8</issue><spage>1165</spage><epage>1173</epage><pages>1165-1173</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background:The association between cardiovascular risk factors (CVRF) and the risk of coronary events is widely acknowledged. Whether individual risk factors may be associated with distinct plaque characteristics is currently unclear. We investigated the relationship between CVRF and coronary plaque burden and phenotype.Methods and Results:We assessed coronary atherosclerotic plaque characteristics by optical coherence tomography in 67 patients with stable coronary artery disease undergoing coronary angiography. The plaque burden and the distinct plaque phenotypes were compared with regard to different CVRF. Overall plaque burden was significantly greater in patients with diabetes mellitus (P=0.010), prediabetes (P=0.035) and obesity (P=0.024), and correlated with the number of CVRF (R=0.358, P=0.003). Patients with diabetes had a greater extent of fibroatheroma (P=0.015), calcific fibroatheroma (P=0.031), thin-cap fibroatheroma (TCFA-P=0.011) and plaque erosion (P=0.002). Obese patients showed a greater extent of fibroatheroma (P=0.007), TCFA (P=0.015) and macrophage load (P=0.043). The number of CVRF correlated with fibroatheroma (R=0.425, P<0.001), calcific fibroatheroma (R=0.321, P=0.008), TCFA (R=0.347, P=0.004), macrophage load (R=0.314, P=0.010) and erosion (R=0.271, P=0.029). In the multivariate analysis, altered glycemic status and obesity were the only independent predictors of TCFA (P=0.026 and P=0.046, respectively), whereas altered glycemic status was the only independent predictor of plaque erosion (P=0.001).Conclusions:Patients with diabetes, prediabetes and obesity show more extensive coronary atherosclerosis and more vulnerable plaque phenotypes.</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>28420816</pmid><doi>10.1253/circj.CJ-17-0054</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1346-9843 |
| ispartof | Circulation Journal, 2017/07/25, Vol.81(8), pp.1165-1173 |
| issn | 1346-9843 1347-4820 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1889765274 |
| source | Freely Accessible Journals |
| subjects | Aged Cardiovascular risk factors Coronary artery disease Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - etiology Diabetes Complications - diagnostic imaging Female Humans Male Middle Aged Obesity - complications Obesity - diagnostic imaging Optical coherence tomography Plaque erosion Plaque, Atherosclerotic - diagnostic imaging Plaque, Atherosclerotic - etiology Prediabetic State - complications Prediabetic State - diagnostic imaging Registries Tomography, Optical Coherence Vulnerable plaque |
| title | Coronary Atherosclerotic Plaque Characteristics and Cardiovascular Risk Factors ― Insights From an Optical Coherence Tomography Study |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T13%3A29%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Coronary%20Atherosclerotic%20Plaque%20Characteristics%20and%20Cardiovascular%20Risk%20Factors%E3%80%80%E2%80%95%20Insights%20From%20an%20Optical%20Coherence%20Tomography%20Study&rft.jtitle=Circulation%20Journal&rft.au=Rosa,%20Roberta%20De&rft.date=2017&rft.volume=81&rft.issue=8&rft.spage=1165&rft.epage=1173&rft.pages=1165-1173&rft.issn=1346-9843&rft.eissn=1347-4820&rft_id=info:doi/10.1253/circj.CJ-17-0054&rft_dat=%3Cproquest_cross%3E1889765274%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c622t-1ea2d5e7a19a0fc4a8a37a424ff4fee71a41ebb1078e5757d439d3b09335da693%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1889765274&rft_id=info:pmid/28420816&rfr_iscdi=true |