Sigma-1 receptor antagonist haloperidol attenuates Ca2+ responses induced by glutoxim and molixan in macrophages

Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor antagonist, antipsychotic haloperidol, significantly inhibits glutoxim- and molixan-induced Ca 2+ -response in peritoneal macrophages. These results indicate possible involvement of sigma-1 receptors in the signa...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2017, Vol.472 (1), p.74-76
Main Authors: Krutetskaya, Z. I., Milenina, L. S., Naumova, A. A., Butov, S. N., Antonov, V. G., Nozdrachev, A. D.
Format: Article
Language:English
Subjects:
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Life Sciences
Molecular Biology
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Summary:Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor antagonist, antipsychotic haloperidol, significantly inhibits glutoxim- and molixan-induced Ca 2+ -response in peritoneal macrophages. These results indicate possible involvement of sigma-1 receptors in the signal cascade induced by glutoxim or molixan and leading to intracellular Ca 2+ concentration increase in macrophages.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672917010227