A Proton Magnetic Resonance Spectroscopic Study in Autism Spectrum Disorder Using a 3-Tesla Clinical Magnetic Resonance Imaging (MRI) System: The Anterior Cingulate Cortex and the Left Cerebellum

The pathophysiology of autism spectrum disorder (ASD) is not fully understood. We used proton magnetic resonance spectroscopy to investigate metabolite concentration ratios in the anterior cingulate cortex and left cerebellum in ASD. In the ACC and left cerebellum studies, the ASD group and intellig...

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Bibliographic Details
Published in:Journal of child neurology 2017-07, Vol.32 (8), p.731-739
Main Authors: Ito, Hiromichi, Mori, Kenji, Harada, Masafumi, Hisaoka, Sonoka, Toda, Yoshihiro, Mori, Tatsuo, Goji, Aya, Abe, Yoko, Miyazaki, Masahito, Kagami, Shoji
Format: Article
Language:English
Subjects:
Adolescent
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Autism Spectrum Disorder - diagnostic imaging
Autism Spectrum Disorder - pathology
Cerebellum - diagnostic imaging
Child
Child, Preschool
Choline - metabolism
Creatine - metabolism
Female
gamma-Aminobutyric Acid - metabolism
Gyrus Cinguli - diagnostic imaging
Humans
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Male
Proton Magnetic Resonance Spectroscopy
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Summary:The pathophysiology of autism spectrum disorder (ASD) is not fully understood. We used proton magnetic resonance spectroscopy to investigate metabolite concentration ratios in the anterior cingulate cortex and left cerebellum in ASD. In the ACC and left cerebellum studies, the ASD group and intelligence quotient- and age-matched control group consisted of 112 and 114 subjects and 65 and 45 subjects, respectively. In the ASD group, γ-aminobutyric acid (GABA)+/ creatine/phosphocreatine (Cr) was significantly decreased in the anterior cingulate cortex, and glutamate (Glu)/Cr was significantly increased and GABA+/Cr was significantly decreased in the left cerebellum compared to those in the control group. In addition, both groups showed negative correlations between Glu/Cr and GABA+/Cr in the left cerebellum, and positive correlations between GABA+/Cr in the anterior cingulate cortex and left cerebellum. ASD subjects have hypoGABAergic alterations in the anterior cingulate cortex and hyperglutamatergic/hypoGABAergic alterations in the left cerebellum.
ISSN:0883-0738
1708-8283
DOI:10.1177/0883073817702981