Protective effects of tempol in an experimental ovarian ischemia–reperfusion injury model in female Wistar albino rats

The aim of this study was to investigate the antioxidant effects of tempol on ovarian ischemia–reperfusion (I/R) injury in rats. Forty female Wistar albino rats were randomly divided into 5 groups: Group I, sham; Group II, ischemia (I); Group III, I/R; Group IV, I/R + tempol 30 mg/kg i.p; Group V, I...

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Bibliographic Details
Published in:Canadian journal of physiology and pharmacology 2017-07, Vol.95 (7), p.861-865
Main Authors: Pınar, Neslihan, Soylu Karapınar, Oya, Özcan, Oğuzhan, Atik Doğan, Esin, Bayraktar, Suphi
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants (Nutrients)
Care and treatment
Catalase - metabolism
Cyclic N-Oxides - pharmacology
Cytoprotection - drug effects
Female
Health aspects
Ischemia
ischémie–reperfusion dans l’ovaire
Malondialdehyde - metabolism
ovarian ischemia–reperfusion
Ovary - drug effects
Ovary - metabolism
Ovary - pathology
Oxidative stress
Oxidative Stress - drug effects
Oxidoreductases - metabolism
Pharmacology
Physiology
Rats
Rats, Wistar
Reperfusion
Reperfusion injury
Reperfusion Injury - metabolism
Reperfusion Injury - prevention & control
Rodents
Spin Labels
stress oxydatif
Studies
Tempol
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Summary:The aim of this study was to investigate the antioxidant effects of tempol on ovarian ischemia–reperfusion (I/R) injury in rats. Forty female Wistar albino rats were randomly divided into 5 groups: Group I, sham; Group II, ischemia (I); Group III, I/R; Group IV, I/R + tempol 30 mg/kg i.p; Group V, I/R + tempol 50 mg/kg i.p. Oxidative stress index (OSI) was significantly higher in the ischemia group and the I/R group than in the sham group. Catalase levels were significantly lower in the I/R group than in the I/R + tempol 30 mg/kg i.p. and the I/R + tempol 50 mg/kg i.p. groups. Glutathione peroxidase levels were lower in the I/R group than in the I/R + tempol 30 mg/kg i.p. and the I/R + tempol 50 mg/kg i.p. groups. MDA levels were significantly lower in the I/R + tempol 30 mg/kg i.p. group and the I/R + tempol 50 mg/kg i.p. group than in the I/R group. The levels of the histopathological parameters were significantly decreased in the I/R + tempol 50 mg/kg i.p. group compared with the I/R group. Tempol can be used for reducing ovarian I/R injury.
ISSN:0008-4212
1205-7541
DOI:10.1139/cjpp-2016-0309