Adipokines as atherothrombotic risk factors in obese subjects: associations with haemostatic markers and common carotid wall thickness

• Published in: Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2017-06, Vol.27 (6), p.571-580
• Main Authors: Csongrádi, Éva, Káplár, Miklós, Nagy Jr, Béla, Koch, Christian A, Juhász, Attila, Bajnok, László, Varga, Zsuzsa, Seres, Ildikó, Karányi, Zsolt, Magyar, Mária T, Oláh, László, Facskó, Andrea, Kappelmayer, János, Paragh, György
• Format: Article
• Language: English
• Subjects: Adipokines; Adipokines - blood; Adult; Atherosclerosis; Atherosclerosis - blood; Atherosclerosis - diagnostic imaging; Atherosclerosis - etiology; Biomarkers - blood; Blood Platelets - metabolism; Cardiovascular; Carotid Artery Diseases - blood; Carotid Artery Diseases - diagnostic imaging; Carotid Artery Diseases - etiology; Carotid Artery, Common - diagnostic imaging; Carotid Intima-Media Thickness; Case-Control Studies; Common carotid intima-media thickness; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Haemostasis; Hemostasis; Humans; Male; Middle Aged; Obesity; Obesity - blood; Obesity - complications; Obesity - diagnosis; Platelet Activation; Risk Factors; Thrombosis - blood; Thrombosis - diagnostic imaging; Thrombosis - etiology
• ISSN: 0939-4753; 1590-3729
• DOI: 10.1016/j.numecd.2017.02.007

Abstract Background and aims Some crucial associations between obesity-related altered adipokine levels and the main factors of atherosclerotic, atherothrombotic processes are not fully known. We analysed the relationships of classic adipokines, namely leptin, resistin, adiponectin, tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) with the markers of platelet activation, including mean platelet volume (MPV), platelet surface/soluble P-selectin, platelet-derived microparticles (PMPs), the parameters of coagulation abnormalities and common carotid intima-media thickness (IMT) in obese patients with or without atherosclerotic comorbidities in comparison to age- and sex-matched controls. Methods and results We enrolled 154 obese individuals, including 98 suffering from atherosclerotic concomitant conditions, 56 free of atherosclerotic comorbidities and 62 healthy controls. Plasma levels of leptin, resistin, adiponectin, TNF-α, IL-6, soluble P-selectin, and plasminogen activator inhibitor-1 antigen (PAI-1 ag) were analysed by ELISA. Platelet surface P-selectin and PMPs were measured by flow cytometry. IMT was detected by ultrasonography. Adipokines were closely associated with markers of platelet hyperactivity, hypercoagulability, hypofibrinolysis and IMT. Significant independent associations were found between leptin and platelet count (p