Mechanisms of chemotherapy-induced ovarian damage in breast cancer patients

Abstract Fertility preservation in breast cancer patients is an increasingly relevant topic. In the present paper we review available data on the mechanism of ovarian damage caused by anticancer agents currently used for the treatment of breast cancer. We also describe current methods to preserve fe...

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Bibliographic Details
Published in:Critical reviews in oncology/hematology 2017-05, Vol.113, p.90-96
Main Authors: Codacci-Pisanelli, Giovanni, Del Pup, Lino, Del Grande, Maria, Peccatori, Fedro A
Format: Article
Language:English
Subjects:
Adult
Alkylating agents
Antineoplastic Agents, Alkylating - adverse effects
Antineoplastic Agents, Alkylating - pharmacology
Antineoplastic Agents, Alkylating - therapeutic use
Apoptosis
Breast Neoplasms - drug therapy
Cryopreservation
DNA Damage
Female
Fertility - drug effects
Fertility Preservation - methods
Fertility protection
Hematology, Oncology and Palliative Medicine
Humans
Oocyte exhaustion
Oocytes
Ovarian damage
Ovary - drug effects
Ovary - pathology
Premature ovarian failure
Primary Ovarian Insufficiency - chemically induced
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Summary:Abstract Fertility preservation in breast cancer patients is an increasingly relevant topic. In the present paper we review available data on the mechanism of ovarian damage caused by anticancer agents currently used for the treatment of breast cancer. We also describe current methods to preserve fertility including oocytes or ovarian tissue freezing and administration of LH-RHa during chemotherapy. The aim of the paper is to provide clinical oncologists with an adequate knowledge of the subject to enable them to give a correct counselling to young women that must receive chemotherapy and want to increase their possibilities of maintaining fertility.
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2017.03.009