Effects of Different Modes of Hypobaric Hypoxia on the Content of Epigenetic Factors in the Rat in Neurons of Rat Neocortex

We studied the effects of different modes of hypobaric hypoxia on the content of epigenetic factors acH3K24, meH3K9, and meDNA modulating conformational characteristics of chromatin and gene expression in neurons of associative complex of rat parietal neocortex. Severe destructive hypoxia dramatical...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-04, Vol.162 (6), p.722-725
Main Authors: Samoilov, M. O., Churilova, A. V., Glushchenko, T. S., Rybnikova, E. A.
Format: Article
Language:English
Subjects:
Acetylation
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Death - drug effects
Chromatin
DNA binding proteins
DNA Methylation
Epigenesis, Genetic
Epigenetic inheritance
Epigenetics
Female
Gene expression
Gene regulation
Genes
Histones - genetics
Histones - metabolism
Hormesis
Hypoxia
Hypoxia - genetics
Hypoxia - metabolism
Hypoxia - pathology
Internal Medicine
Laboratory Medicine
Methylation
Neocortex
Neocortex - drug effects
Neocortex - metabolism
Neocortex - pathology
Neurons
Neurons - drug effects
Neurons - metabolism
Neurons - pathology
Neuroprotection
Neuroprotective Agents - pharmacology
Oxygen - pharmacology
Pathology
Protein Processing, Post-Translational
Rats
Rats, Wistar
Severity of Illness Index
Transcription (Genetics)
Transcription factors
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Summary:We studied the effects of different modes of hypobaric hypoxia on the content of epigenetic factors acH3K24, meH3K9, and meDNA modulating conformational characteristics of chromatin and gene expression in neurons of associative complex of rat parietal neocortex. Severe destructive hypoxia dramatically reduced the level of acH3K24 in 3 h after the end of exposure and increased meH3K9 and meDNA content. By contrast, 3-fold (but not single) adaptive exposure to moderate hypobaric hypoxia that produced a neuroprotective effect enhanced neuronal acH3K24 expression and decreased both meH3K9 and meDNA levels. Elevated acH3K24 content facilitates, while increased content of meH3K9 hampers binding of transcription factors to the target genes. At the same time, increased expression of meDNA suppresses transcription. The role of modification of epigenetic mechanisms in the regulation of proadaptive genes under the effects of hypoxic exposure according to various protocols is discussed.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3697-y