Mitochondrial Function in Allergic Disease

Purpose of the Review The connections between allergy, asthma and metabolic syndrome are becoming increasingly clear. Recent research suggests a unifying mitochondrial link between the diverse phenotypes of these interlinked morbidities. The scope of this review is to highlight cellular mechanisms,...

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Bibliographic Details
Published in:Current allergy and asthma reports 2017-05, Vol.17 (5), p.29-29, Article 29
Main Authors: Iyer, Divyaanka, Mishra, Navya, Agrawal, Anurag
Format: Article
Language:English
Subjects:
Allergens
Allergies
Allergology
Asthma
Asthma - immunology
Basic and Applied Science (I Lewkowich
Comorbidity
Humans
Hypersensitivity - immunology
Medicine
Medicine & Public Health
Metabolic Syndrome - immunology
Metabolism
Mitochondria
Mitochondria - immunology
Mitochondrial DNA
Section Editor
Topical Collection on Basic and Applied Science
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Summary:Purpose of the Review The connections between allergy, asthma and metabolic syndrome are becoming increasingly clear. Recent research suggests a unifying mitochondrial link between the diverse phenotypes of these interlinked morbidities. The scope of this review is to highlight cellular mechanisms, epidemiology and environmental allergens influencing mitochondrial function and its importance in allergy and asthma. We briefly also consider the potential of mitochondria-targeted therapies in prevention and cure. Recent Findings Recent research has shown allergy, asthma and metabolic syndrome to be linked to mitochondrial dysfunction. Environmental pollutants and allergens are observed to cause mitochondrial dysfunction, primarily by inducing oxidative stress and ROS production. Malfunctioning mitochondria change the bioenergetics of the cell and its metabolic profile to favour systemic inflammation, which drives all three types of morbidities. Summary Given the existing experimental evidence, approaches targeting mitochondria (e.g. antioxidant therapy and mitochondrial replacement) are being conducted in relevant disease models—with some progressing towards clinical trials, making mitochondrial function the focus of translational therapy research in asthma, allergy and linked metabolic syndrome.
ISSN:1529-7322
1534-6315
DOI:10.1007/s11882-017-0695-0